无症状感染者值得警惕!中国疾控中心报告近9000例新冠病毒患者研究:基本传染数3.77

2020-02-13 xujing 文韬 中国循环杂志

近日,预印本网站Medrxiv发表了一项纳入近9000例新冠肺炎患者的研究显示,该疾病预计病死率约3.06%,病毒潜伏期4.8天,基本传染数(R0)为3.77。老年男性患者是高危人群。研究分析了2020年1月26日前上报中国疾病预防控制中心的8866例患者,4021例为确诊病例,占45%,余55%的患者为疑似病例。确诊患者中有41%来自武汉市。确诊患者中,69.9%的患者发生轻度肺炎,25.5%的

近日,预印本网站Medrxiv发表了一项纳入近9000例新冠肺炎患者的研究显示,该疾病预计病死率约3.06%,病毒潜伏期4.8天,基本传染数(R0)为3.77。老年男性患者是高危人群。

研究分析了2020年1月26日前上报中国疾病预防控制中心的8866例患者,4021例为确诊病例,占45%,余55%的患者为疑似病例。确诊患者中有41%来自武汉市。

确诊患者中,69.9%的患者发生轻度肺炎,25.5%的患者发生重症肺炎,4.5%没有肺炎。严重肺炎多见于老年男性。

作者指出,无症状感染的患者值得警惕,有必要使评估轻度或无症状的传染性,以及对流行趋势的影响。

比如,一名从武汉回来的年轻女子虽然没症状,但被怀疑传染了她在河南的三名亲戚。

研究者估算,新冠病毒的基本传染数R0达3.77,即每位患者传染人数是3.77人。

这比之前《新英格兰医学杂志》上,国家疾控中心团队基于425名患者流行病学资料得出的R0值2.2要高。

作者认为,新冠病毒的传染性比SARS病毒稍高,明显高于中东呼吸综合征(MERS)病毒。

研究者推算,新冠病毒的预计病死率约为3.06%,低于SARS病毒(9.2%)和MERS病毒(34.4%)。

研究者特别指出,研究仅仅分析了在2020年1月26日之前10天有症状的患者,这样就有漏报了轻症肺炎病例(该研究为4.5%),这样可能高估了死亡率。

研究还发现,男性发病率为0.31/10万人,高于女性(0.27/10万人)。

此外,该研究4021例确诊患者中,30-65岁的患者超七成,近半数(47.7%)患者年龄在50岁以上。年龄分布在疑似患者中同样如此。

研究还提示,男性、年龄≥60岁、严重肺炎以及确诊延迟的患者病死率高。

此外,通过对125例有明确暴露史的患者进行潜伏期分析,研究者估计新冠病毒的潜伏期是4.8天。

研究者认为,与SARS病毒和MERS病毒一样,新冠病毒易感染男性人群,这可能与亚洲男性肺组织内ACE2受体表达多有关。

这项研究由解放军军事医学科学院微生物流行病研究所、中国疾控中心和美国佛罗里达大学学者联合完成。

来源:

Yang Yang, et al. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. Medrxiv, Posted February 11, 2020.

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    2020-02-15 zutt
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    2020-02-13 公卫新人

    新冠肺炎,疫情何时才能消失

    0