AP&T: 有回肠储袋的无症状患者行内窥镜检查活动会增加患储袋炎的风险

2019-11-30 不详 MedSci原创

存在回肠储袋的无症状溃疡性结肠炎(UC)患者行内镜活动的重要性不言而喻,但是无症状患者的内窥镜囊活动与随后的囊炎发展是否有关尚无定论。

背景
存在回肠储袋的无症状溃疡性结肠炎(UC)患者行内镜活动的重要性不言而喻,但是无症状患者的内窥镜囊活动与随后的囊炎发展是否有关尚无定论。

方法
本项研究回顾性分析了UC患者临床数据,这些患者接受了回肠储袋肛门吻合术(IPAA)的全结肠切除术。储袋疾病活动指数(PDAI)症状评分为零的无症状患者接受了监测性储袋镜检查。内窥镜活动被分级为0:正常,1:粘膜炎症或2:粘膜破裂(溃疡和/或糜烂)。主要结局为原发性急性特发性储袋炎,定义为PDAI评分≥7,症状持续时间少于4周且对标准抗生素有反应,否则不符合继发性储袋炎的标准。次要结果是慢性特发性储袋炎,定义为PDAI评分≥7,尽管使用标准抗生素治疗,但症状持续超过4周。

结果
本项研究纳入143例无症状囊袋患者。指数监视式腔镜检查后的中位随访时间为3.03 [IQR 1.24-4.60]年。44名(31%)患者出现原发性急性特发性储袋炎,12名(8.4%)患者发生慢性特发性储袋炎。2级内窥镜囊袋活动与急性囊炎的发展有关(HR 2.39,95%CI 1.23-4.67),而与慢性囊炎无关(HR 1.76,95%CI 0.53-5.87)。内窥镜正常囊粘膜的组织学炎症与急性或慢性囊炎无关。

结论
在近四分之一的无症状IPAA患者行肠镜检查出现粘膜破裂,并与急性囊炎风险增加相关。

原始出处:

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    2019-12-02 zhaojie88
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