J Cosmet Dermatol:皮内注射A型肉毒杆菌毒素并不能治疗紫外线照射引起的色素沉着

2022-08-15 MedSci原创 MedSci原创

黄褐斑、日光性色斑和炎症后色素沉着(PIH)等色素沉着症是由紫外线照射诱发或加剧的常见皮肤病,这可能对患者的生活质量产生负面影响,并引起美容问题。

黄褐斑、日光性色斑和炎症后色素沉着(PIH)等色素沉着症是由紫外线照射诱发或加剧的常见皮肤病,这可能对患者的生活质量产生负面影响,并引起美容问题。尽管现有大量的治疗方案,包括局部和全身用药、化学换肤和激光等,但由于治疗效果有限,出现治疗诱发的PIH,以及经常复发,所以治疗色素沉着疾病的成功率有限。A型肉毒杆菌毒素(BTX-A)已被广泛用于治疗各种皮肤病的实验中。最近的研究表明,BTX-A对紫外线B(UVB)引起的皮肤色素沉着有预防作用。近日,发表于J Cosmet Dermatol的一项前瞻性、双盲、随机对照试验研究了BTX-A治疗UVB诱导的人类色素沉着的效果。

研究设计UVB照射腹部,诱发五个独立的色素沉着方块。照射7天后,所有方块被随机分配到5个干预组:对照组、0.9%正常生理盐水注射、12单位(1:2.5)、6单位(1:5)和4单位(1:7.5)的BTX-A注射。在注射后的14天、21天和28天,获得亮度指数(L*)、由盲法医生评定的色素沉着改善得分以及参与者的满意度得分。

结果,最终15名参与者(平均年龄36.9岁,Fitzpatrick皮肤类型III-IV)完成了这项研究。根据平均L*和色素沉着改善评分,BTX-A(1:2.5)处理的部位在所有时间点的色素沉着程度都较低。然而,各组之间没有统计学上的显著差异。参与者对对照组的部位最为满意。

综上所述,该研究结果表明,皮内注射BTX-A对UVB引起的色素沉着没有治疗作用,据推测这是由于其对黑色素生成的作用延迟所致。然而,BTX-A注射液在治疗其他色素沉着症方面的作用需要进一步阐明。

 

原始出处:

Natthachat Jurairattanaporn, et al., Study of botulinum toxin type A for the treatment of ultraviolet B-induced hyperpigmentation: A prospective, randomized, controlled trial. J Cosmet Dermatol. 2022 Aug;21(8):3343-3350. doi: 10.1111/jocd.14966.  

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    2022-11-23 tcm99hq
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    2023-07-12 sunylz
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    2023-07-03 一闲
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