JACC:早产是孕妇远期缺血性心脏病的独立危险因素

2020-07-05 MedSci原创 MedSci原创

据报道,早产的妇女将来患心脏代谢紊乱的风险会增加。然而,他们患缺血性心脏病(IHD)的长期风险以及这种风险是否由共同的家族因素引起尚不清楚。这项研究的目的是评估不同妊娠事件对妇女IHD的长期风险。

据报道,早产的妇女将来患心脏代谢紊乱的风险会增加。然而,他们患缺血性心脏病(IHD)的长期风险以及这种风险是否由共同的家族因素引起尚不清楚。这项研究的目的是评估不同妊娠事件对妇女IHD的长期风险。

本研究纳入分析了瑞典1973-2015年期间单次妊娠的2189190名妇女,经过平均4750万人年次随访,共有49955名(2.3%)妇女被诊断为IHD,在妊娠后的10年内,与足月妊娠相比,早产(<37周)相关的IHD危险比是2.47(95% [CI]: 2.16 - 2.82),这些风险虽然在远期随访期间有所降低,但仍显着升高(早产与足月,10至19年:aHR:1.86;95%CI:1.73-1.99;20-29年:aHR:1.52;95%CI:1.45-1.59;30-43年:aHR:1.38;95%CI:1.32-1.45)。这些结果似乎并不归因于家族内部的共同遗传或环境因素。另外,额外的早产与IHD风险的进一步增加有关。

研究结果显示,早产是孕妇远期缺血性心脏病的强独立危险因素。

原始出处:

Casey C et al.Pre-Term Delivery and Risk of Ischemic Heart Disease in Women.JACC.2020 July.

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    2020-11-19 hbwxf
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