A&R:类风湿性关节炎与肺功能测量指标的关系

2021-12-01 MedSci原创 MedSci原创

类风湿性关节炎与限制性和阻塞性肺部模式的几率增加有关

     目的:以一般人群做对照,研究类风湿性关节炎(RA)与肺活量测定中肺部模式的类型和严重程度的独立关系。

     方法:在这项横断面研究中,研究人员调查了RA与英国生物库中因研究目的而接受肺活量测定的受试者肺功能测量值之间的关联。RA病例是根据自我报告和当前使用的缓解疾病的抗风湿药/糖皮质激素确定的。对照是没有RA的普通受试者。结果测量包括预测的1秒内持续用力呼气量 (FEV1%)和预测的用力肺活量百分比(FVC%)、肺活量测定模式(限制性或阻塞性)以及限制性或阻塞性模式的严重程度。使用多变量回归来估计与对照组相比RA病例的影响,校正了年龄、性别、体重指数和吸烟状况/包年。

     结果:在350,776名接受肺活量测定的受试者中(平均年龄56.3岁;55.8%为女性;45.5% 曾吸烟),研究者确定了2,008例接受治疗的RA。在多变量分析中,与对照相比RA与较低的 FEV1% (β=2.93 [95% CI 3.63, 2.24])FVC% (β=2.08 [95% CI 2.72, 1.45]) FEV1/FVC (β=0.008 [95% CI 0.010, 0.005])RA还与限制性模式(比值比OR 1.36 [95% CI 1.21, 1.52])和阻塞性模式(OR 1.21 [95% CI 1.07, 1.37])相关,与混杂因素无关,并且与严重限制性和阻塞性模式相关性最强。

      结论RA与限制性和阻塞性肺部模式的几率增加有关,这种关系不能用包括吸烟状况的混杂因素解释。除了限制性肺部疾病,临床医生还应该意识到气道阻塞可能是RA的肺部表现。

 

出处:

Prisco, L., Moll, M., Wang, J., Hobbs, B.D., Huang, W., Martin, L.W., Kronzer, V.L., Huang, S., Silverman, E.K., Doyle, T.J., Cho, M.H. and Sparks, J.A. (2021), Relationship Between Rheumatoid Arthritis and Pulmonary Function Measures on Spirometry in the UK Biobank. Arthritis Rheumatol, 73: 1994-2002. https://doi.org/10.1002/art.41791

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