JAMA:又添证据!减肥“神药”索马鲁肽再传捷报!

2021-03-26 MedSci原创 MedSci原创

在完成20周疗程后,超重或肥胖的人群仍可在随后的索马鲁特维持治疗中持续减轻体重。

如果要问新年以来,什么药最火,我想没有任何人会对诺和诺德(Novo Nordisk)公司开发的胰高血糖素样肽-1(GLP-1)受体激动剂索马鲁肽(semaglutide)有异议。

众所周知,肥胖是造成预期寿命缩短的重要因素,同时也是包括糖尿病、高血压等慢性病的重要危险因素。因此,减肥无疑是治疗各种代谢疾病的基础。近年来的研究进展显示,减肥手术可以降低肥胖人群长期相对死亡风险,但肥胖人群的死亡率仍然高于一般人口。

新年伊始,顶级期刊《新英格兰医学杂志》(NEJM)率先公布了索马鲁肽治疗肥胖症患者的3期临床试验结果,发现参与者平均减重15.3kg,这另众多超重和肥胖人士看到了希望。

紧接着,包括《柳叶刀》《美国医学会杂志》杂志等在内的顶刊也再次传来佳音——每周一次皮下注射索马鲁特可以使肥胖患者在68周内体重下降幅度更加明显,平均减重17kg上述顶级研究共同验证了索马鲁特对治疗肥胖患者的疗效。

那么,减肥人士最关心的问题莫过于——继续使用索马鲁特治疗对维持肥胖或超重患者体重是否会“耐药”?为此,来自英、美、得、法等众多国家的专家对该问题继续进行了探讨,结果再次发表在《美国医学会杂志》(JAMA)上。

该STEP4试验为从2018年6月至2020年3月,在10个国家的73个研究中心进行随机、双盲、68周的3a期撤药研究,旨在比较超重或肥胖成年人在每周2.4mg索马鲁特治疗20周后,继续每周一次皮下注射或切换至安慰剂进行体重维持(均有生活方式干预)的疗效。

共纳入902名参与者,20周后,803名使用2.4mg索马鲁特维持剂量(89.0%)。将上述参与者随机(2:1)分配到48周继续皮下注射(n = 535)或切换到安慰剂(n = 268)两组。主要终点是第20周至第68周体重的百分比变化;次要终点是腰围、收缩压和身体功能的变化。

在完成20周疗程的803名研究参与者中,平均体重下降10.6%,上述参与者中787名参与者(98.0%)完成了最终试验。总的来说,在继续使用索马鲁特的情况下,从第20周到第68周的平均体重变化为-7.9%,而改用安慰剂后为+6.9%(差异=-14.8,95% CI,-16.0~-13.5)。

此外,腰围(差异-9.7cm)、收缩压(-3.9mmHg)和SF-36身体功能评分(2.5)也随着继续皮下注射索马鲁特而改善。继续使用索马鲁特的参与者中有49.1%报告了胃肠道事件,而安慰剂为26.1%;两组分别有2.4%和2.2%的参与者因不良事件而停止治疗。

由此可见,明星减肥药果真没让人失望。该研究表明,在完成20周疗程后,超重或肥胖的人群仍可在随后的索马鲁特维持治疗中持续减轻体重。

 

参考文献:

Rubino D, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. Published online March 23, 2021. doi:10.1001/jama.2021.3224

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    2021-05-14 1245f0b2m95暂无昵称

    可以买到吗😁

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  2. [GetPortalCommentsPageByObjectIdResponse(id=965601, encodeId=bbc596560113, content=可以买到吗😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ec32482279, createdName=1245f0b2m95暂无昵称, createdTime=Fri May 14 16:34:01 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036544, encodeId=885010365446b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048362, encodeId=a310104836276, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951483, encodeId=1cae95148327, content=很早之前就关注了 跟利拉鲁肽类似 都可以减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18df2566800, createdName=妙酒, createdTime=Fri Mar 26 22:39:33 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951475, encodeId=4ca99514e509, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51705231149, createdName=1479ea96m27暂无昵称, createdTime=Fri Mar 26 21:49:09 CST 2021, time=2021-03-26, status=1, ipAttribution=)]
    2021-03-27 旺医

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  3. [GetPortalCommentsPageByObjectIdResponse(id=965601, encodeId=bbc596560113, content=可以买到吗😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ec32482279, createdName=1245f0b2m95暂无昵称, createdTime=Fri May 14 16:34:01 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036544, encodeId=885010365446b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048362, encodeId=a310104836276, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951483, encodeId=1cae95148327, content=很早之前就关注了 跟利拉鲁肽类似 都可以减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18df2566800, createdName=妙酒, createdTime=Fri Mar 26 22:39:33 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951475, encodeId=4ca99514e509, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51705231149, createdName=1479ea96m27暂无昵称, createdTime=Fri Mar 26 21:49:09 CST 2021, time=2021-03-26, status=1, ipAttribution=)]
    2021-03-27 CHANGE

    什么时候有懒人用的减肥神药?

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  4. [GetPortalCommentsPageByObjectIdResponse(id=965601, encodeId=bbc596560113, content=可以买到吗😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ec32482279, createdName=1245f0b2m95暂无昵称, createdTime=Fri May 14 16:34:01 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036544, encodeId=885010365446b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048362, encodeId=a310104836276, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951483, encodeId=1cae95148327, content=很早之前就关注了 跟利拉鲁肽类似 都可以减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18df2566800, createdName=妙酒, createdTime=Fri Mar 26 22:39:33 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951475, encodeId=4ca99514e509, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51705231149, createdName=1479ea96m27暂无昵称, createdTime=Fri Mar 26 21:49:09 CST 2021, time=2021-03-26, status=1, ipAttribution=)]
    2021-03-26 妙酒

    很早之前就关注了 跟利拉鲁肽类似 都可以减肥

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=965601, encodeId=bbc596560113, content=可以买到吗😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ec32482279, createdName=1245f0b2m95暂无昵称, createdTime=Fri May 14 16:34:01 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036544, encodeId=885010365446b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048362, encodeId=a310104836276, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Mar 27 00:38:06 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951483, encodeId=1cae95148327, content=很早之前就关注了 跟利拉鲁肽类似 都可以减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18df2566800, createdName=妙酒, createdTime=Fri Mar 26 22:39:33 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951475, encodeId=4ca99514e509, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51705231149, createdName=1479ea96m27暂无昵称, createdTime=Fri Mar 26 21:49:09 CST 2021, time=2021-03-26, status=1, ipAttribution=)]
    2021-03-26 1479ea96m27暂无昵称

    学习了

    0

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