JAHA:颈动脉内膜中层厚度和其他颈动脉超声指标与痴呆的关系

2021-04-18 MedSci原创 MedSci原创

较大的颈动脉内膜中膜厚度,中膜间直径和较低的颈动脉扩张性与痴呆症发生风险增加相关。这些结果表明,动脉粥样硬化和颈动脉僵硬可能与痴呆风险有关。

颈动脉内膜中层厚度增加、中膜间直径、颈动脉斑块有无和扩张性降低是血管疾病的预测指标。这些指标可能与脑血管疾病有关,因此可能是痴呆症和与阿尔茨海默氏病相关痴呆症的一种血管表现形式。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在ARIC(社区的动脉粥样硬化风险)研究中,研究人员旨在评估颈动脉测量指标和动脉僵硬程度与痴呆之间的关系。

在1990年至1992年期间,研究人员共对12459名ARIC参与者进行了颈动脉超声检查,并对痴呆进行随访至2017年。研究人员通过面谈和电话根据受试者的认知状态评估、住院出院代码和死亡证明代码来确定痴呆病例,并使用Cox比例风险模型来估计痴呆事件的风险比(HRs)。

参加者在基线时的年龄为57±6岁,女性为57%,黑人为23%。在24年的中位随访时间内,研究人员共确定了2224例痴呆症患者。经过多变量调整后,与最低的五分位数相比,中年时颈动脉内膜中层厚度和中膜间直径最高五分位数与痴呆风险增加相关(分别有HR [95%CIs]为1.25 [1.08–1.45]和1.22 [1.04–1.43])。颈动脉斑块与痴呆之间没有显著相关性(HR [95%CI]为1.06 [0.97-1.15])。较高的扩张性与较低的痴呆风险相关(最高与最低的五分位数HR [95%CI]为0.76 [0.63-0.91])。

由此可见,较大的颈动脉内膜中膜厚度,中膜间直径和较低的颈动脉扩张性与痴呆症发生风险增加相关。这些结果表明,动脉粥样硬化和颈动脉僵硬可能与痴呆风险有关

原始出处:

Wendy Wang.et al.Association of Carotid Intima‐Media Thickness and Other Carotid Ultrasound Features With Incident Dementia in the ARIC‐NCS.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020489

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    2021-04-20 zhaohui6731
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    2021-04-18 junJUN

    老年人痴呆何药可用??

    0

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