Chest:急性呼吸窘迫综合征与右心室的相关性

2017-03-08 MedSci MedSci原创

急性呼吸窘迫综合征与不良的临床结果相关,尽管有最佳的护理标准,但合并的死亡率仍然高达40%。当前的治疗策略主要是基于改善氧合作用和肺顺应性以使得呼吸机诱导的肺损伤最小化。已经证明,患者可以良好耐受相对的低氧血症,并且改善氧合不一定转化为存活益处。心力衰竭,特别是右心室功能障碍,通常在中度至重度急性呼吸窘迫综合征中发生,并且根据报道是导致死亡的主要决定因素之一。超声心动图显示的急性呼吸窘迫综合征患者

急性呼吸窘迫综合征与不良的临床结果相关,尽管有最佳的护理标准,但合并的死亡率仍然高达40%。

当前的治疗策略主要是基于改善氧合作用和肺顺应性以使得呼吸机诱导的肺损伤最小化。

已经证明,患者可以良好耐受相对的低氧血症,并且改善氧合不一定转化为存活益处。

心力衰竭,特别是右心室功能障碍,通常在中度至重度急性呼吸窘迫综合征中发生,并且根据报道是导致死亡的主要决定因素之一。超声心动图显示的急性呼吸窘迫综合征患者发生右心室功能障碍的患病率在22%至50%不等。

尽管右心室功能障碍和死亡率之间没有确定的因果关系,但严重的右心室功能障碍与死亡率增加有关。这可能由于一些影响右心室功能的不利因素,包括缺氧性肺血管收缩,高碳酸血症和具有高驱动压力的有创通气。

右心室功能障碍的早期诊断可能具有一定的益处。然而,用于前瞻性评估急性呼吸窘迫综合征中右心室的超声心动图标记(定性和定量)没有在充分动力的研究中测试。

全面了解右心室功能障碍和急性呼吸窘迫综合征的病理生理学,讨论可用的诊断模式和治疗选择将改善这个群体的临床结果。

原始出处:
Zochios V, Parhar K, et al. 'The Right Ventricle in Acute Respiratory Distress Syndrome'. Chest. 2017 Mar 3. pii: S0012-3692(17)30263-5. doi: 10.1016/j.chest.2017.02.019. 

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    2017-06-14 Smile2680
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