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Am J Transl Res：Wnt4表达的丧失通过牙髓炎中的JNK信号传导抑制牙髓干细胞的牙源性潜力

2019-05-04 不详 网络

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基于牙髓干细胞（DPSC）的炎性病症的牙源性再生在牙髓炎的过程中是重要的。据报道，DPSC在炎症条件下丧失了牙源性再生的可能性。本研究旨在确定DPSCs在炎症微环境中牙源性分化受损的机制。我们使用重组慢病毒Wnt4和Wnt4 siRNA调节Wnt4表达。进行碱性磷酸酶（ALP）和茜素红S（ARS）染色以及实时PCR以评估具有上调或下调的Wnt4的DPSC的成骨分化潜能。此外，SP600125用于抑

基于牙髓干细胞（DPSC）的炎性病症的牙源性再生在牙髓炎的过程中是重要的。据报道，DPSC在炎症条件下丧失了牙源性再生的可能性。本研究旨在确定DPSCs在炎症微环境中牙源性分化受损的机制。

我们使用重组慢病毒Wnt4和Wnt4 siRNA调节Wnt4表达。进行碱性磷酸酶（ALP）和茜素红S（ARS）染色以及实时PCR以评估具有上调或下调的Wnt4的DPSC的成骨分化潜能。此外，SP600125用于抑制潜在的下游因子JNK1，并评估DPSC的成骨分化能力。如图所示，Wnt4在炎性条件下在DPSC中下调。抑制DPSCs中Wnt4的表达负调控牙源性分化。在LPS处理的DPSC中过表达Wnt4促进了牙源性分化。此外，JNK1负责Wnt4介导的DPSCs牙源性分化。

总之，Wnt4可通过在炎性条件下通过DPSC损害牙源性再生的过程中影响JNK信号传导途径起作用。

原始出处：

Zhong TY, Zhang ZC, et al., Loss of Wnt4 expression inhibits the odontogenic potential of dental pulp stem cells through JNK signaling in pulpitis. Am J Transl Res. 2019 Mar 15;11(3):1819-1826. eCollection 2019.

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    2019-08-30 bsmagic9140

    #TRA#

    0

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    2019-08-06 jxrzshh

    #牙髓#

    0

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    2019-09-07 ms3025846204744509

    #Transl#

    0

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    2019-05-06 hb2011ye

    #牙髓炎#

    0

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    2019-05-06 ms6519009802973839

    #牙髓干细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1657167, encodeId=7869165e16763, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Fri Aug 30 02:43:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669768, encodeId=1eb11669e6820, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Aug 06 11:43:00 CST 2019, time=2019-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067438, encodeId=47b5206e43846, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Sep 07 16:43:00 CST 2019, time=2019-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496172, encodeId=616214961e23e, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Mon May 06 11:43:00 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544904, encodeId=09b01544904e4, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Mon May 06 11:43:00 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598651, encodeId=d654159865176, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon May 06 11:43:00 CST 2019, time=2019-05-06, status=1, ipAttribution=)]
    2019-05-06 zhwj

    #WNT#

    0