Stroke:CT灌注成像可用来筛选卒中患者的血管内治疗

2017-04-22 MedSci MedSci原创

背景:可应用不同的影响学检查评估卒中患者是否进行血管内治疗。研究者试图确定与CT平扫相比, CT灌注成像(CTP)是否可改善血管内治疗的预后。方法: 前瞻性收集登记记录在2010年9月到2016年3月期间的前循环卒中患者,这些患者在三级医院行支架血栓取栓术。将选择CTP的患者与CT平扫的患者相比。主要终点是90天的改良Rankin量表(mRS)。结果:共纳入602例患者。选择CTP的患者(n =

背景:可应用不同的影响学检查评估卒中患者是否进行血管内治疗。研究者试图确定与CT平扫相比, CT灌注成像(CTP)是否可改善血管内治疗的预后。

方法: 前瞻性收集登记记录在2010年9月到2016年3月期间的前循环卒中患者,这些患者在三级医院行支架血栓取栓术。将选择CTP的患者与CT平扫的患者相比。主要终点是90天的改良Rankin量表(mRS)。

结果:共纳入602例患者。选择CTP的患者(n = 365,61%)更年轻(P = 0.02),有较少的合并症。CTP(n = 365,61%)与90天的良好mRS变化(aOR= 1.49;95% CI,1.06-2.09;P = 0.02),良好预后(90天mRS评分0-2分:52.9%vs40.4%;P = 0.005),脑梗死溶栓再灌注(54.8%对40.1%;P<0.001),最终梗死体积较小(24.7mL[ 9.8-63.1 mL]与34.6 mL[ 13.1-88 mL];P = 0.017),和死亡率较低(16.6%VS26.8%;P = 0.005)有关。当校正年龄,美国国立卫生院卒中量表(NIHSS)评分、葡萄糖(n = 424),CTP仍然与90天的良好mRS(P = 0.016),死亡率较低(P = 0.02)、再灌注率较高(P<0.001)相关。CTP更好的预测6小时后(通过Logistic回归模型: Akaike信息准则:199.35 vs 287.49和贝叶斯信息准则196.71vs283.27:)和那些与阿尔伯塔卒中计划早期CT评分≤7(Akaike信息准则:216.69 vs 334.96和贝叶斯信息准则:213.6 vs 329.94)患者的功能结果。

结论:接受支架取栓治疗的患者,选择CTP与的良好的mRS相关。未来需要进行前瞻性研究。

原文出处:

Bouslama M, Haussen DC, et al. Computed Tomographic Perfusion Selection and Clinical Outcomes After Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke. 2017 Apr 7.


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