Eur Heart J:低剂量秋水仙碱对冠心病患者的疗效和安全性分析

2021-03-27 MedSci原创 MedSci原创

低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险。更低的心血管死亡被更高的非心血管死亡所抵消,所以全因死亡率没有差异。

最近的随机试验表明,在最近的心肌梗塞或慢性冠心病患者中,将低剂量秋水仙碱添加到基于指南的治疗中可使患者获得益处。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员进行了系统的综述和荟萃分析,以获得秋水仙碱对主要不良心血管事件(MACE)影响的最佳估计。

研究人员检索了动脉粥样硬化患者长期使用秋水仙碱的随机临床试验,检索截止至2020年9月。该研究的主要终点是MACE,包括心肌梗塞、卒中或心血管死亡的综合结局。

研究人员合并了包含11816名患者的五项试验的结果。578例患者发生主要终点。秋水仙碱将主要终点事件的风险降低了25%[相对风险(RR)为0.75、95%置信区间(CI)为0.61-0.92;P=0.005],心肌梗死风险降低了22%(RR为0.78,95%CI为0.64–0.94; P=0.010),卒中风险降低了46%(RR为0.54,95%CI为0.34–0.86; P=0.009),冠状动脉血运重建风险降低了23%(RR为0.77,95%CI为0.66-0.90;P<0.001)。研究人员观察到全因死亡没有差异(RR为1.08,95%CI为0.71–1.62;P=0.73),心血管死亡的发生率较低(RR为0.82,95%CI为0.55–1.23;P=0.34),是由更高的非心血管死亡发生率所抵消(RR为1.38,95%CI为0.99–1.92;P=0.060)。

该荟萃分析表明,低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险。更低的心血管死亡被更高的非心血管死亡所抵消,所以全因死亡率没有差异。

原始出处:

Aernoud T L Fiolet,et al.Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab115

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    2021-08-19 ms7000000816152103

    可以学到很多

    0

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    2021-08-05 146e31c1m79暂无昵称

    学习了

    0

  4. 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topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 29 06:21:14 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951798, encodeId=e62e951e9815, content=我学到了很多东西谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Sun Mar 28 10:00:05 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951731, encodeId=1839951e3190, content=低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2021-05-24 Aidy

    低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险。更低的心血管死亡被更高的非心血管死亡所抵消,所以全因死亡率没有差异。

    0

  5. 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    2021-03-29 slcumt
  6. 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  7. 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  8. 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authenticateStatus=null, createdAvatar=null, createdBy=6dd15472738, createdName=ms1000001324078343, createdTime=Sun Mar 28 06:53:15 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-29 zhaojie88
  9. 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topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 29 06:21:14 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951798, encodeId=e62e951e9815, content=我学到了很多东西谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Sun Mar 28 10:00:05 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951731, encodeId=1839951e3190, content=低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2021-03-28 1436749007

    我学到了很多东西谢谢老师

    0

  10. 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    2021-03-28 ms1000001324078343

    低剂量秋水仙碱降低了MACE以及心肌梗塞、卒中、心肌梗死和需要进行冠脉血运重建的风险!

    0

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