J Endod:下牙槽阻滞麻醉失败后阿替卡因或利多卡因行附加韧带内注射的效果比较:一项随机双盲实验

2018-12-14 lishiting MedSci原创

这篇研究的目的是为了比较和评估在下牙槽阻滞麻醉失败后采用2%利多卡因或4%阿替卡因作为附加韧带内注射的麻醉效果。

这篇研究的目的是为了比较和评估在下牙槽阻滞麻醉失败后采用2%利多卡因或4%阿替卡因作为附加韧带内注射的麻醉效果。

106名下颌第一或第二磨牙诊断为有症状的不可逆牙髓炎患者首先接受了含1:80,000肾上腺素2%利多卡因的下牙槽阻滞麻醉。采用Heft-Parker直观类比标度评估牙髓治疗过程中的疼痛情况。82名麻醉失败的患者再随机分为2组:组1接受每个牙根0.6 mL的含1:80,000肾上腺素4%阿替卡因的韧带内注射,组2接受含1:80,000肾上腺素2%利多卡因注射。随后,牙髓治疗再重新开始。最初的阻滞麻醉和后来附加的韧带内注射的麻醉成功标准是在开髓和根管预备过程中无痛或轻微疼痛(less than 55 mm on the Heft-Parker visual analog scale)。使用指压脉搏血氧计监测患者心率。采用Pearson chi-square检验评估麻醉成功率,显著性水平设置为5%。T检验评估患者心率变化。

结果显示,患者接受4%阿替卡因的附加韧带内注射麻醉成功率为66%,而接受2%利多卡因的成功率为78%。2者间无显著性差异(χ2 = 1.51, P = .2)。不同麻醉剂对心率均无明显影响。

结论:在最初阻滞麻醉无效后,采用4%阿替卡因和2%利多卡因均明显提高麻醉的成功率,并且2者间无明显差异。

原始出处:

Aggarwal V, Singla M, et al. Efficacy of Articaine Versus Lidocaine Administered as Supplementary Intraligamentary Injection after a Failed Inferior Alveolar Nerve Block: A Randomized Double-blind Study. J Endod. 2018 Dec 5. pii: S0099-2399(18)30656-3. doi: 10.1016/j.joen.2018.09.012.

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    2019-07-08 小微940490

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2078408, encodeId=86d220e8408d1, content=<a href='/topic/show?id=4b2b9e845a0' target=_blank style='color:#2F92EE;'>#阿替卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97845, encryptionId=4b2b9e845a0, topicName=阿替卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat May 25 05:11:00 CST 2019, time=2019-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369297, encodeId=a88c36929e6c, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Mon Jul 08 16:44:30 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288848, encodeId=e367128884894, content=<a href='/topic/show?id=0b1e322e85e' target=_blank style='color:#2F92EE;'>#利多卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32278, encryptionId=0b1e322e85e, topicName=利多卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507417, encodeId=0696150e4178a, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573076, encodeId=c5dd15e307632, content=<a href='/topic/show?id=fef43e52220' target=_blank style='color:#2F92EE;'>#双盲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37522, encryptionId=fef43e52220, topicName=双盲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3115807173, createdName=xlxchina, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046695, encodeId=036e1046695f9, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Dec 14 14:11:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355392, encodeId=7948355392a6, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Dec 14 12:59:06 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355387, encodeId=2dba35538e28, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Fri Dec 14 11:55:48 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-16 xlxchina
  6. [GetPortalCommentsPageByObjectIdResponse(id=2078408, encodeId=86d220e8408d1, content=<a href='/topic/show?id=4b2b9e845a0' target=_blank style='color:#2F92EE;'>#阿替卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97845, encryptionId=4b2b9e845a0, topicName=阿替卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat May 25 05:11:00 CST 2019, time=2019-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369297, encodeId=a88c36929e6c, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Mon Jul 08 16:44:30 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288848, encodeId=e367128884894, content=<a href='/topic/show?id=0b1e322e85e' target=_blank style='color:#2F92EE;'>#利多卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32278, encryptionId=0b1e322e85e, topicName=利多卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507417, encodeId=0696150e4178a, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573076, encodeId=c5dd15e307632, content=<a href='/topic/show?id=fef43e52220' target=_blank style='color:#2F92EE;'>#双盲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37522, encryptionId=fef43e52220, topicName=双盲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3115807173, createdName=xlxchina, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046695, encodeId=036e1046695f9, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Dec 14 14:11:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355392, encodeId=7948355392a6, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Dec 14 12:59:06 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355387, encodeId=2dba35538e28, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Fri Dec 14 11:55:48 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-14 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2078408, encodeId=86d220e8408d1, content=<a href='/topic/show?id=4b2b9e845a0' target=_blank style='color:#2F92EE;'>#阿替卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97845, encryptionId=4b2b9e845a0, topicName=阿替卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat May 25 05:11:00 CST 2019, time=2019-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369297, encodeId=a88c36929e6c, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Mon Jul 08 16:44:30 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288848, encodeId=e367128884894, content=<a href='/topic/show?id=0b1e322e85e' target=_blank style='color:#2F92EE;'>#利多卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32278, encryptionId=0b1e322e85e, topicName=利多卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507417, encodeId=0696150e4178a, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573076, encodeId=c5dd15e307632, content=<a href='/topic/show?id=fef43e52220' target=_blank style='color:#2F92EE;'>#双盲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37522, encryptionId=fef43e52220, topicName=双盲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3115807173, createdName=xlxchina, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046695, encodeId=036e1046695f9, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Dec 14 14:11:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355392, encodeId=7948355392a6, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Dec 14 12:59:06 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355387, encodeId=2dba35538e28, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Fri Dec 14 11:55:48 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-14 一个字-牛

    学习了谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2078408, encodeId=86d220e8408d1, content=<a href='/topic/show?id=4b2b9e845a0' target=_blank style='color:#2F92EE;'>#阿替卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97845, encryptionId=4b2b9e845a0, topicName=阿替卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat May 25 05:11:00 CST 2019, time=2019-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369297, encodeId=a88c36929e6c, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=526e2567988, createdName=小微940490, createdTime=Mon Jul 08 16:44:30 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288848, encodeId=e367128884894, content=<a href='/topic/show?id=0b1e322e85e' target=_blank style='color:#2F92EE;'>#利多卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32278, encryptionId=0b1e322e85e, topicName=利多卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507417, encodeId=0696150e4178a, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573076, encodeId=c5dd15e307632, content=<a href='/topic/show?id=fef43e52220' target=_blank style='color:#2F92EE;'>#双盲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37522, encryptionId=fef43e52220, topicName=双盲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3115807173, createdName=xlxchina, createdTime=Sun Dec 16 02:11:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046695, encodeId=036e1046695f9, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Dec 14 14:11:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355392, encodeId=7948355392a6, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Dec 14 12:59:06 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355387, encodeId=2dba35538e28, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Fri Dec 14 11:55:48 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-14 lietome24

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

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