CGH:L-肉毒碱可减少肝硬化患者肌肉痉挛

2015-08-05 MedSci MedSci原创

根据一项研究发表在8月出版的《临床胃肠病学和肝脏病学》杂志表示,(每日健康)-左卡尼汀对减少肝硬化患者肌肉痉挛似乎是安全有效的。来自东京武藏野红十字医院的Hiroyuki Nakanishi和他的同事们前瞻性评估了左卡尼汀的效用(每天三次,每次300毫克(19名参与者)或每天四次(23名参与者)进行为期八周的实验),检测该剂量的左卡尼汀对肝硬化患者减少肌肉痉挛的作用。研究人员发现,在研究末期,所有

根据一项研究发表在8月出版的《临床胃肠病学和肝脏病学》杂志表示,(每日健康)-左卡尼汀对减少肝硬化患者肌肉痉挛似乎是安全有效的。


来自东京武藏野红十字医院的Hiroyuki Nakanishi和他的同事们前瞻性评估了左卡尼汀的效用(每天三次,每次300毫克(19名参与者)或每天四次(23名参与者)进行为期八周的实验),检测该剂量的左卡尼汀对肝硬化患者减少肌肉痉挛的作用。

研究人员发现,在研究末期,所有参与者的肌肉痉挛程度降低了88.1%,28.6%的病人肌肉痉挛现象已消失。总的来说,用直观模拟标度尺评估肌肉痉挛的程度从基线开始就显著降低(P < 0.0001)。服用更高剂量的左卡尼汀8周后能显著减少更大比例患者肌肉痉挛现象(43.5%,1200毫克/天剂量组比较10.5%,900毫克/天剂量组,P = 0.037)。研究结果没有不良事件发生。

“左卡尼汀的应用对治疗患肌肉痉挛的肝硬化患者可能是一个有前途的治疗方法。”作者写道

原始出处:
Nakanishi H, Kurosaki M, Tsuchiya K, Nakakuki N, Takada H, Matsuda S, Gondo K, Asano Y, Hattori N, Tamaki N, Suzuki S, Yasui Y, Hosokawa T, Itakura J, Takahashi Y, Izumi N.L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1540-3 

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    2016-03-03 chendoc242
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    2015-08-07 apoenzyme
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    2015-08-06 hlycom3356

    对目前研究提供了极大帮助

    0

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