Int J Cardiol:D型性格对冠心病患者内皮功能损害的预测价值!

2018-03-01 xing.T MedSci原创

由此可见,D型性格与男性冠心病患者内皮功能受损有关。这种关联在不同时间较为强劲,独立于抑郁症状,并且支持D型性格对冠心病患者心血管健康具有不良影响的观点。

D型性格(较多的消极情感和社交抑制)与心血管事件和冠状动脉斑块的严重程度相关。D型性格是否与功能性血管舒缩功能异常相关仍是未知的。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员分析了D型性格与冠心病患者内皮功能障碍之间的关联。

在基线时,180例冠心病患者(90%的男性;平均年龄为58岁)完成了D型(DS14)和抑郁量表检查,并进入为期12周的运动计划。研究人员评估了基线、3个月和12个月时肱动脉血流介导的血管扩张(FMD)和循环CD34+/KDR+/CD45+dim的内皮祖细胞(EPCs)。研究人员采用logistic回归和线性混合模型分析了内皮功能。

研究人员发现D型性格与基线、3个月和12个月FMD下降有关 (混合模型分析,P=0.04),对临床特征、运动训练和抑郁进行调整后,D型性格与EPCs降低无明显相关性(P=0.07)。年龄和吸烟与FMD和EPCs显著相关。使用FMD<5.5%作为截止值,在基线时,D型性格患者往往有血管内皮功能障碍(24/37=65%),相比于非D性格患者(63/143=44%);比值比为3.03,95%可信区间为1.04-8.80。在12月(比值比为3.43,95%可信区间为1.01-11.64)内皮功能障碍的前瞻性分析和男性患者的亚组分析中证实了D型性格的意义。

由此可见,D型性格与男性冠心病患者内皮功能受损有关。这种关联在不同时间较为强劲,独立于抑郁症状,并且支持D型性格对冠心病患者心血管健康具有不良影响的观点。

原始出处:

JohanDenollet,et al. Predictive value of Type D personality for impaired endothelial function in patients with coronary artery disease.International Journal of Cardiology.2018. https://doi.org/10.1016/j.ijcard.2018.02.064

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