Gut:幽门螺杆菌根除治疗大幅降低西方人群胃腺癌风险

2018-02-01 zhangfan MedSci原创

研究认为幽门螺杆菌根除治疗可显著降低瑞典人群胃腺癌和非贲门癌风险

胃幽门螺杆菌感染是非贲门型胃腺癌的重要危险因素。近日研究人员考察了西方人群中胃幽门螺杆菌清除后胃腺癌和非贲门癌的风险变化。

研究于2005-12年间在瑞典开展,从瑞典处方药登记信息获得胃幽门螺杆菌根除治疗信息,从瑞典癌症登记处检索胃腺癌信息。比较胃幽门螺杆菌根除治疗人群和一般人群的胃腺癌与非贲门癌风险。

随访期间,95176名患者接受了胃幽门螺杆菌根除治疗,总计随访351018患者年,其中75人(0.1%)发生胃腺癌,69人(0.1%)发生非贲门腺癌,根除治疗后,患者胃腺癌风险随着时间推移降低到一般风险水平:治疗后1-3年的累积肿瘤风险为8.65(95% CI 6.37-11.46),3-5年后的累积风险为2.02(95% CI 1.25-3.09)而5-7.5年后的累积风险降低至0.31 (95% CI 0.11-0.67)。对于非贲门腺癌,治疗后的累积风险分别为10.74 (95% CI 7.77-14.46), 2.67 (95% CI 1.63-4.13)和0.43 (95% CI 0.16- 0.93)。

研究认为幽门螺杆菌根除治疗可显著降低瑞典人群胃腺癌和非贲门癌风险。

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    2018-06-21 kcb069
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    2018-07-05 风铃830
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    2019-01-12 sjq027
  5. [GetPortalCommentsPageByObjectIdResponse(id=1811743, encodeId=82e91811e43ac, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Jun 21 11:01:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724793, encodeId=3e821e24793b2, content=<a href='/topic/show?id=cbf949106b5' target=_blank style='color:#2F92EE;'>#幽门螺杆菌根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49106, encryptionId=cbf949106b5, topicName=幽门螺杆菌根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de833685139, createdName=rgjl, createdTime=Wed Mar 21 08:01:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683661, encodeId=08d81683661bd, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Thu Jul 05 18:01:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061711, encodeId=ee352061e11b9, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Jan 12 21:01:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027383, encodeId=f599202e38344, content=<a href='/topic/show?id=80e262286bf' target=_blank style='color:#2F92EE;'>#根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62286, encryptionId=80e262286bf, topicName=根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jan 05 03:01:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284832, encodeId=3b22284832e0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:36 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284831, encodeId=1d4d2848317d, content=谢谢!分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:30 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305922, encodeId=6e2a1305922f0, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sat Feb 03 01:01:00 CST 2018, time=2018-02-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1811743, encodeId=82e91811e43ac, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Jun 21 11:01:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724793, encodeId=3e821e24793b2, content=<a href='/topic/show?id=cbf949106b5' target=_blank style='color:#2F92EE;'>#幽门螺杆菌根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49106, encryptionId=cbf949106b5, topicName=幽门螺杆菌根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de833685139, createdName=rgjl, createdTime=Wed Mar 21 08:01:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683661, encodeId=08d81683661bd, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Thu Jul 05 18:01:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061711, encodeId=ee352061e11b9, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Jan 12 21:01:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027383, encodeId=f599202e38344, content=<a href='/topic/show?id=80e262286bf' target=_blank style='color:#2F92EE;'>#根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62286, encryptionId=80e262286bf, topicName=根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jan 05 03:01:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284832, encodeId=3b22284832e0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:36 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284831, encodeId=1d4d2848317d, content=谢谢!分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:30 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305922, encodeId=6e2a1305922f0, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sat Feb 03 01:01:00 CST 2018, time=2018-02-03, status=1, ipAttribution=)]
    2018-02-03 微笑人参

    好好学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1811743, encodeId=82e91811e43ac, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Jun 21 11:01:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724793, encodeId=3e821e24793b2, content=<a href='/topic/show?id=cbf949106b5' target=_blank style='color:#2F92EE;'>#幽门螺杆菌根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49106, encryptionId=cbf949106b5, topicName=幽门螺杆菌根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de833685139, createdName=rgjl, createdTime=Wed Mar 21 08:01:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683661, encodeId=08d81683661bd, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Thu Jul 05 18:01:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061711, encodeId=ee352061e11b9, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Jan 12 21:01:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027383, encodeId=f599202e38344, content=<a href='/topic/show?id=80e262286bf' target=_blank style='color:#2F92EE;'>#根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62286, encryptionId=80e262286bf, topicName=根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jan 05 03:01:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284832, encodeId=3b22284832e0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:36 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284831, encodeId=1d4d2848317d, content=谢谢!分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:30 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305922, encodeId=6e2a1305922f0, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sat Feb 03 01:01:00 CST 2018, time=2018-02-03, status=1, ipAttribution=)]
    2018-02-03 微笑人参

    谢谢!分享.谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1811743, encodeId=82e91811e43ac, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Jun 21 11:01:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724793, encodeId=3e821e24793b2, content=<a href='/topic/show?id=cbf949106b5' target=_blank style='color:#2F92EE;'>#幽门螺杆菌根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49106, encryptionId=cbf949106b5, topicName=幽门螺杆菌根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de833685139, createdName=rgjl, createdTime=Wed Mar 21 08:01:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683661, encodeId=08d81683661bd, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Thu Jul 05 18:01:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061711, encodeId=ee352061e11b9, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Jan 12 21:01:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027383, encodeId=f599202e38344, content=<a href='/topic/show?id=80e262286bf' target=_blank style='color:#2F92EE;'>#根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62286, encryptionId=80e262286bf, topicName=根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jan 05 03:01:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284832, encodeId=3b22284832e0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:36 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284831, encodeId=1d4d2848317d, content=谢谢!分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Sat Feb 03 22:18:30 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305922, encodeId=6e2a1305922f0, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Sat Feb 03 01:01:00 CST 2018, time=2018-02-03, status=1, ipAttribution=)]