Ann Rheum Dis:幼年性关节炎和妊娠结局:基于人群的队列研究

2017-07-14 xiangting MedSci原创

这项研究发现儿童期JIA和持续到成年的JIA女性与对照人口相比,孕妇和婴儿并发症的风险升高。

关于幼年性关节炎(JIA)女性妊娠结局的报道很少见。这项研究的目的是评估在诊断为JIA的大型当代女性队列中的妊娠结局。

在1992年至2011年间全国瑞典人口为基础的队列研究中,确定了JIA女性中有1807例分娩,对照分娩为1 949 202。由于JIA是一种异质性疾病,JIA女性的分娩分为儿童期JIA(n = 1169),持续到成年的JIA(n = 638)。用广义估计方程估计ORs和95%CI。

两个亚组JIA女性的早产风险均升高,特别是有医学指征的早产:儿童期JIA调整OR(aOR)为1.74(1.35-2.67)和持续成年JIA的aOR为4.12(2.76-6.15)。持续到成年的JIA与早产相关(aOR 3.14,1.58-6.24),自发性早产(aOR 1.63,1.11-2.39),孕龄小(aOR 1.84,1.19-2.85),早发性先兆子痫(aOR 6.28,2.68-13.81)和迟发性先兆子痫(aOR 1.96,1.31-2.91)。儿童期JIA的女性患者仅剖宫产风险增加(aOR 1.42,1.66-1.73)和引产(aOR 1.45,1.18-1.77)。

这项研究发现儿童期JIA和持续到成年的JIA女性与对照人口相比,孕妇和婴儿并发症的风险升高。因此在怀孕和分娩期间,应加大对JIA女性的监测。

原始出处:
Katarina Remaeus,et al. Juvenile onset arthritis and pregnancy outcome: a population-based cohort study. Ann Rheum Dis. 30 June 2017.

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    2017-07-20 wxl882001

    学习一下

    0

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    2017-07-16 lmm397
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    2017-07-14 thlabcde

    好东西学习了!

    0

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