The Lancet Psychiatry:精神分裂症或是致残率更高的精神疾病

2022-05-29 MedSci原创 MedSci原创

近年来,精神心理健康日益引起高度关注,严重影响大众身心健康。据数据显示,全球范围内超过5000万人患有精神障碍,而且是全球残疾的第九大原因。在以往研究中,通常使用全球疾病负担研究自上而下的汇总统计来估

近年来,精神心理健康日益引起高度关注,严重影响大众身心健康。据数据显示,全球范围内超过5000万人患有精神障碍,而且是全球残疾的第九大原因。在以往研究中,通常使用全球疾病负担研究自上而下的汇总统计来估计精神障碍对社会的影响,而对于精神障碍如何影响人们的一生很少有相关研究。

近日,发表在Lancet子刊的一项研究显示,精神分裂症是最具致残性的精神疾病,且合并症越多的个体将具有更高的健康损失比例(HeLP)权重,残疾程度更高。

在这项队列研究中,研究人员收集了丹麦精神病中心研究登记册690万名丹麦居民进行研究,以了解与18种精神和药物使用障碍相关的残疾负担。通过健康损失比例(HeLP)估计个体水平的残疾程度,也就是意味着,合并症越多HeLP权重越高,残疾程度也就越高。

研究结果发现,重性抑郁症是最常见的疾病。精神分裂症是男女合计的失能引起的寿命损失年(YLDs)的主要原因(每10万人年的YLDs273-3[95 % CI 232-3-313-6]),男性中占总数的42%,在女性中占总数的30另外,精神分裂症是最具致残性的精神疾病,在所有精神障碍中HeLP最高为73%。在大麻使用障碍、其他药物使用障碍和多动症患者中,HeLP69-83%。相比之下,自闭症谱系障碍、行为障碍和精神分裂症患者中,HeLP11-23%

综上,传统上,精神障碍的影响是针对整个国家提出的,但在这项研究中,我们专注于个人层面的不同类型的精神和物质使用障碍的人。精神分裂症是最具致残性的精神疾病,并展示了自闭症,焦虑症和精神分裂症等疾病如何在不同年龄段造成残疾。

原始出处

Nanna Weye, MScRegister-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark, The Lancet Psychiatry. doi.org/10.1016/S2215-0366(21)00029-8

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    2021-05-04 howi
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    2021-03-21 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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