Neurology:胶质纤维酸性蛋白(GFAP)抗体阳性患者的临床特征:一项法国队列研究

2021-12-04 Naomi MedSci原创

GFAP自身免疫主要与伴有前驱症状的急性/亚急性脑膜脑脊髓炎有关,肿瘤和T细胞功能障碍是其常见的触发因素。大多数患者遵循单相疗程,结果良好。

      胶质纤维酸性蛋白(GFAP)是成体星形胶质细胞中主要的中间丝蛋白。针对GFAP的抗体(Ab)已被确认为最近报道的一种疾病的生物标志物,称为自身免疫性GFAP星形细胞病变。建议在脑脊液中检测GFAP-Ab,方法是在大鼠脑组织上进行间接免疫荧光和使用GFAPα的细胞分析(IFA和CBA)。自身免疫性GFAP星形细胞病变是一种罕见的实体,在成人和儿童中主要被描述为伴有或不伴有视盘水肿的脑膜脑脊髓炎,并存的肿瘤或自身免疫性疾病和相关的神经抗体并不少见。激素反应是常见的,尽管复发病例和罕见的致命问题已被描述。虽然自首次报告以来,在国家层面已经发表了一些重要的研究,关于GFAP星形细胞病变仍有几个悬而未决的问题:发病机制知之甚少;临床异质性已有报道,没有统一的诊断标准;评估复发风险和残疾结局的预后因素缺失;但仍然缺乏治疗建议。近日,有研究人员报道了法国首例GFAP自身抗体患者,描述他们的临床、生物学和影像学特征,并评估临床过程和结果。

      研究人员回顾了自2017年以来,来自两个法国转诊中心的所有脑脊液胶质纤维酸性蛋白抗体检测呈阳性的患者,通过免疫组织化学检测,并通过表达人胶质纤维酸性蛋白α的细胞进行基于细胞的分析确认。

  •  
  • 共鉴定出46例GFAP抗体阳性患者。
  • 发病年龄中位数为43岁,其中65%为男性。82%的患者出现感染性前驱症状。22%的患者发现了其他自身免疫性疾病,11%的患者同时存在神经自身抗体。肿瘤的发生率为24%,T细胞功能障碍的发生率为23%。最常见的症状是亚急性脑膜脑炎(85%),57%的病例伴有小脑功能障碍。其他临床表现包括脊髓炎(30%)、视力(35%)和周围神经系统受累(24%)。
  • MRI表现为血管周围放射状强化32%,脑室周围T2高信号41%,脑干受累31%,软脑膜强化26%,可逆性脾病变4例。
  • 尽管临床表现严重,但33/40名患者的病程为单相,与最后一次随访的良好结果相关(Rankin评分≤为2:89%)。
  • 成人和儿童的特征相似。
  • 32例患者接受免疫治疗。11/22例GFAP抗体转阴者。

      GFAP自身免疫主要与伴有前驱症状的急性/亚急性脑膜脑脊髓炎有关,肿瘤和T细胞功能障碍是其常见的触发因素。大多数患者遵循单相疗程,结果良好。

文献来源:Dumonceau AG, Ameli R, Rogemond V, et al. Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study [published online ahead of print, 2021 Nov 19]. Neurology. 2021;10.1212/WNL.0000000000013087. doi:10.1212/WNL.0000000000013087

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2022-10-08 mgqwxj
  2. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2022-04-26 yinhl1978
  3. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2022-08-04 mnda
  4. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1968680, encodeId=54d4196868096, content=<a href='/topic/show?id=bf70e24322' target=_blank style='color:#2F92EE;'>#FAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7243, encryptionId=bf70e24322, topicName=FAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Oct 08 05:37:41 CST 2022, time=2022-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001631, encodeId=b3c82001631a7, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Apr 26 20:37:41 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970982, encodeId=cac519e098205, content=<a href='/topic/show?id=4e1ee98203' target=_blank style='color:#2F92EE;'>#GFAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7982, encryptionId=4e1ee98203, topicName=GFAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Thu Aug 04 15:37:41 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948132, encodeId=6dc819481323c, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 27 15:37:41 CST 2022, time=2022-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809902, encodeId=b09f1809902b3, content=<a href='/topic/show?id=7a98840e353' target=_blank style='color:#2F92EE;'>#胶质纤维酸性蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84073, encryptionId=7a98840e353, topicName=胶质纤维酸性蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Feb 05 21:37:41 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842986, encodeId=9be5184298670, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Aug 14 09:37:41 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399959, encodeId=ec801399959f2, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Sun Dec 05 13:37:41 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-05 neurowu

相关资讯

Clin Exp Rheumatol:类风湿性关节炎自身抗体水平与疾病活动性的关联取决于基线炎症

在非利妥昔单抗治疗的RA患者中,疾病活动性与自身抗体水平变化的关联不是一成不变的,而是随着基线炎症迹象的增加而增强(ESR、VAS、关节肿胀、触痛、晨僵)。

Transfusion:红细胞表面糖蛋白 A 的自身抗体影响循环白细胞的激活状态

外周血中的中性粒细胞和单核细胞暴露于针对 RBC 表面 GPA 的抗体,例如 M 或 N 抗原,可能会引发活化表型。

J INTERN MED:较高针对apoB100 p210的自身抗体水平与女性较低的房颤发生率相关

心房颤动(AF)与全身和心房组织炎症相关。这些结果支持自身体液免疫与房颤之间的关联。

Mol Psychiatr: 母亲血浆中的生物标志物或可用于预测后代的自闭症类型

利用机器学习,加州大学戴维斯心理研究所的研究人员发现了几种与自闭症的诊断和严重程度高度相关的母体自身抗体模式。

Circulation:心脏骤停的自身抗体特征!

心脏骤停是一种悲剧,在世界范围内,大约每90秒就有一人死于心脏骤停。幸存者通常会接受检查,以确定骤停的原因。但约5%-10%的心脏骤停仍原因不明。因为心律失常是大多数心脏骤停的基础,而且越来越多的证据

Frontiers in Immunology: IL-40:一种新的B细胞相关细胞因子在利妥昔单抗治疗类风湿性关节炎后上调减少,并与疾病活性、自身抗体和NETosis相关

白细胞介素40 (IL-40)是一种新发现的B细胞相关细胞因子,该研究主要探究IL-40在类风湿性关节炎(RA)中的功能。

拓展阅读

Alzheimer&Dementia:新发现——临床前阿尔茨海默病的诊断性和预后性血浆生物标志物

这些发现强调了GFAP和p-tau对临床前AD的诊断和纵向监测潜力。

Brain: 脑创伤后8个月的胶质纤维酸性蛋白和神经丝蛋白轻链水平可预测5年后脑结构改变

后期的血液生物标志物水平可用于识别具有进行性神经损伤高风险的创伤性脑损伤幸存者。

JAMA Neurol:AD起病全过程,胶质纤维酸性蛋白水平在血浆和脑脊液如何变化?

准确检测阿尔茨海默病(AD)的血液生物标记物在临床常规和临床试验中得到了迅速的应用。本研究提示,血浆胶质纤维酸性蛋白是检测和追踪反应性星形胶质细胞增生症和A-β病理的敏感生物标志物,早在AD早期已发生

Translational Psychiatry:单相抑郁症患者脑脊液GFAP浓度增加 

单相抑郁症患者脑脊液中GFAP水平升高;因此,GFAP水平在未来可能作为重度抑郁症的一个额外的生物标志物。

JAMA子刊:神经丝光(NfL)水平可预测早产儿未来视网膜病变和神经发育障碍风险

脑损伤生物标记物神经丝光(NfL)和胶质纤维酸性蛋白(GFAP)的血清水平在早产后是如何变化的,这些生物标记物与新生儿发病率相关吗?