Lancet:特发性痛觉刺激用于耐药性重度抑郁的治疗

2018-04-27 zhangfan MedSci原创

研究认为10Hz特发性痛觉刺激对于耐药性抑郁的治疗效果非劣于皮层反复经颅磁刺激,但其治疗时间短,患者依从性更强

重度抑郁障碍患者常常出现药物治疗抗性。利用10 Hz高频,进行左侧背外侧前额叶皮层反复经颅磁刺激(rTMS)是一种有效的非药物重度抑郁治疗手段。特发性痛觉刺激(iTBS)是一种新的rTMS形式,可在3 min内完成治疗。近日研究人员比较了iTBS与rTMS对耐药性抑郁患者的治疗效果。

研究在加拿大开展。18-65岁耐药性或治疗不耐受的重度抑郁患者参与,患者HRSD-17评分18分以上。患者随机接受10Hz的rTMS或iTBS,每周5次,持续4-6周。主要终点是HRSD-17评分变化。

205名患者接受rTMS,209名患者接受iTBS,分别有94%和92%的患者完成研究。4-6周后,rTMS组患者平均HRSD-17评分由23.5下降至13.4;iTBS组由23.6下降至13.4,二种方法效果差异不显著。iTBS组患者自我报告的疼痛强度高于rTMS,组间试验退出率差异不显著。二组最常见的不良事件均为头痛(64 vs 65%)。

研究认为10Hz特发性痛觉刺激对于耐药性抑郁的治疗效果非劣于皮层反复经颅磁刺激,但其治疗时间短,患者依从性更强。

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    2018-12-26 howi
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    2018-04-27 三生有幸9135

    学习一下谢谢分享

    0

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    2018-04-27 wzb521zf

    一起学习学习

    0

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