Allergy Asthma Clin Immunol:过敏和鼻窦炎有什么联系呢?

2022-01-18 AlexYang MedSci原创

来自武汉大学人民医院的研究人员在《Allergy Asthma Clin Immunol》杂志上发表文章,调查了过敏和鼻窦炎之间的关系。

尽管过敏和鼻窦炎之间的关系已进行了广泛的研究,但定义仍然不清楚。虽然有几项研究提出了过敏和慢性鼻窦炎之间的因果关系,但还有几项研究报告说缺乏任何现有的联系。

近期,来自武汉大学人民医院的研究人员在《Allergy Asthma Clin Immunol》杂志上发表文章,调查了过敏和鼻窦炎之间的

研究人员利用2005-2006年全国健康与营养调查中,具有代表性的美国人口样本进行了一项横断面研究(n=7244)。使用自我报告的过敏问卷以及总的和过敏原特异性IgE水平数据进行调查分析。参与者分为阳性和阴性过敏症状组(分别为PAS、NAS),以消除过敏症状对鼻窦炎明显发病率的影响。皮尔逊卡方检验和Durbin Watson检验的线性回归分析用于统计分析。

NAS组中,血清总lgE与鼻窦炎的关系

结果发现,PAS组的鼻窦炎发病率(22.4%;521/2327)明显高于NAS组(7.1%;348/4917)[几率(OR)=3.788,95%置信区间(CI)3.272-4.384,P<0.001]。非过敏组和过敏组的鼻窦炎发病率没有统计学差异。在控制了过敏症状后,致敏状态与PAS组的鼻窦炎发生率之间存在负相关(OR=1.407,95%CI 1.156-1.711,P<0.01)。血清总IgE水平的提高与PAS组和NAS组鼻窦炎发病率的降低相关。在PAS组中,对蟑螂、豚草、黑麦草、百慕大草、橡树、桦树和蓟草等过敏原过敏的参与者的鼻窦炎发病率明显降低。

PAS组中,血清总lgE与鼻窦炎的关系

综上所述,过敏症与鼻窦炎的发病率有关。敏化状态可能会降低鼻窦炎的发病率,且是以抗原特异性的方式

原始出处:

Song Li , Chu-Jin Zhao , Hong-Li Hua et al. The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005-2006. Allergy Asthma Clin Immunol. Dec 2021

 

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    2022-06-06 skhzy
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    2022-01-20 膀胱癌

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