ARTHRIT CARE RES:母亲类风湿性关节炎长期影响后代健康

2017-12-13 海北 MedSci原创

患有类风湿性关节炎(RA)的母亲可能具有影响后代疾病情况的长期风险。近日,来自欧登塞大学医院的研究人员测试了母亲患有RA和后代中15个选定的慢性病组之间是否存在可能的关联。

患有类风湿性关节炎(RA)的母亲可能具有影响后代疾病情况的长期风险。近日,来自欧登塞大学医院的研究人员测试了母亲患有RA和后代中15个选定的慢性病组之间是否存在可能的关联。

这是一项全国范围的队列研究,以丹麦健康登记处为基础,其包括了198911日至20131231日在丹麦出生的所有儿童的数据。该队列包括了2106名患有RA的女性(暴露)生产的婴儿,和1378539名无RA的女性(未暴露)生产的婴儿。研究人员使用Cox比例风险回归模型,考虑大范围的混杂因素,计算儿童和青少年疾病的风险比(HR)。

结果显示,暴露组的儿童甲状腺疾病的HR2.19 (95% CI, 1.14 – 4.21)癫痫HR1.61 (95% CI, 1.16 – 2.25)RAHR2.89 (95% CI, 2.06 – 4.05)。焦虑,人格障碍以及哮喘等慢性肺部疾病的HR值在1.151.16之间,但这些差异无统计学意义。

因此,此项研究的结果表明,与没有RA的母亲所生的孩子相比,在子宫内暴露于母亲的RA与儿童和青少年时期的甲状腺疾病,癫痫,以及RA风险的增加相关。


原始出处:

Line R Jølving et al. Children born by women with rheumatoid arthritis have increased susceptibility for selected chronic diseases - a nationwide cohort studyArthritis Care & Research, 2017; DOI: 10.1002/acr.23461


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    2020-04-11 阿菡

    如何治疗和避免

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    2017-12-17 lofter

    学习了感谢分享

    0

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    2017-12-14 lmm397
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    2017-12-14 zhaojie88
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