Clin Oral Investig:益生菌在治疗复发性口角炎中的疗效

2021-08-20 MedSci原创 MedSci原创

复发性口角炎 (RAS)是最常见的疼痛性口腔粘膜疾病,几乎每个人都会发生。RAS发作时的溃疡疼痛可能会严重影响到进食、说话和吞咽。

复发性口角炎 (RAS)是最常见的疼痛性口腔粘膜疾病,几乎每个人都会发生。RAS发作时的溃疡疼痛可能会严重影响到进食、说话和吞咽。

 

发表于Clin Oral Investig一项随机、对照的临床研究探讨了益生菌在治疗轻微复发性口炎(RAS)方面的有效性。

研究纳入60名成人(A组)和60名儿童(B组)患者,诊断为轻微RAS。两组都被分为两个亚组;AI和BI(试验亚组)和AII和BII(对照亚组)。对于试验亚组,每天连续服用两次益生菌锭,持续5天。在治疗的第0、3和5天,记录溃疡的大小和疼痛程度。调查所有亚组RAS在6个月内的爆发频率。

 

结果显示,与基线相比,所有亚组的RAS都明显改善。然而,就减少疼痛的效果而言,与对照组相比,评价期间AI都有明显的统计学改善。关于减少溃疡面积的效果,与对照组相比,在第5天观察到BI组显著改善。除了在第3天减少疼痛的效果外,AI组和BI组(测试组)之间的有效性指数没有显著差异。BI亚组的爆发频率明显下降。

综上,该研究结果表明,益生菌的局部应用降低了疼痛强度,加速了RAS的愈合。疼痛减轻的效果在成年患者中更为明显,而加速愈合的效果在儿童中更为明显。

 

原始出处:

 

Reham Lotfy Aggour, et al., Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial. Clin Oral Investig. 2021 Apr;25(4):2151-2158. doi: 10.1007/s00784-020-03527-7.  

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    2022-07-06 ms8000001255329993

    学习了

    0

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    2022-02-11 小几洁
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    2021-08-21 仓央嘉措

    益生菌和微生物基因组最近又火热了

    0

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    2021-08-21 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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