J Allergy Clin Immunol Pract:在屋尘螨诱发的鼻炎中,慢性鼻窦炎伴鼻息肉风险如何?

2022-02-18 AlexYang MedSci原创

调查了屋尘螨(DP)诱发的鼻炎的内型是否是CRSwNP和成人发病哮喘的风险因素,并调查了过敏性斑贴试验(DP-APT)评估的对DP超敏性的延迟是否是贡献因素。

局部过敏性鼻炎(LAR)和双重过敏性鼻炎(DAR)与系统过敏性鼻炎(AR)的观察比较,可以提高对过敏在慢性鼻炎伴鼻息肉(CRSwNP)中作用的认识

近期,来自意大利的研究人员在《J Allergy Clin Immunol Pract》上发表文章,调查了屋尘螨(DP)诱发的鼻炎的内型是否是CRSwNP和成人发病哮喘的风险因素,并调查了过敏性斑贴试验(DP-APT)评估的对DP超敏性的延迟是否是贡献因素

研究人员对999名患者队列进行了15年的前瞻性观察研究,包括了468名AR患者,333名LAR患者和198名DAR患者。DAR为在DP引起的局部过敏性鼻炎患者中同时存在因花粉系统过敏引起的季节性疾病。研究设计包括体检、带前鼻镜的耳鼻喉科检查、皮肤点刺试验、血清特异性IgE、DP-APT、带DP的鼻过敏原激发试验、副鼻窦CT扫描、鼻内镜检查和肺活量测定。

研究结果表明,在15年的随访中,194名患者发展为CRSwNP,LAR(28.2%)和DAR(22.2%)的比例均高于AR(12%)。在LAR和DAR中,分别有7.5%和10.6%的患者发展为成年期哮喘,其中68%和71.4%的病例与CRSwNP有时间关联。858名鼻炎患者对DP的超敏反应存在延迟。

另外,DP-ATP是CRSwNP的独立预测因素,提高了鼻粘膜局部过敏性疾病的阳性和阴性预测值。

DP诱导的过敏性鼻炎内型的哮喘发病率情况

综上所述,DP诱导的过敏性鼻炎的内型是CRSwNP的风险因素。LAR和DAR比AR的风险更大。在这些内型中,向CRSwNP的发展往往与成人发病的哮喘有关。对DP过敏的延迟是CRSwNP的一个独立预测因素

 

原始出处:

Huadong Wu , Wei Wan , Hongqun Jiang et al. Prognosis of Idiopathic Sudden Sensorineural Hearing Loss: The Nomogram Perspective. Ann Otol Rhinol Laryngol. Jan 2022.

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