Gastric Cancer: 新发现!保留迷走神经肝分支可减少胃切除术后胆结石形成的风险

2021-01-12 MedSci原创 MedSci原创

随着内镜筛查方案和综合治疗的发展,胃癌患者的预后在发达国家已显著改善,特别是在韩国和日本。因此,临床医生开始更加注重改善患者的功能预后和生活质量。胆石病被称为

      随着内镜筛查方案和综合治疗的发展,胃癌患者的预后在发达国家已显著改善,特别是在韩国和日本。因此,临床医生开始更加注重改善患者的功能预后和生活质量。胆石病被称为胃切除术的长期并发症之一。许多研究中报道,胃切除术后胆囊结石(GBS)的发生率范围从5.2%到15.3%不等。胃切除术后GBS形成率增加的病理生理机制尚未完全了解。GBS形成的潜在原因可能包括迷走神经肝分支的损伤,非生理重建以及术后粘连引起的胆道变形等等。在这项研究中,研究人员旨在评估迷走神经肝支的保留是否可以降低胃切除术后患者GBS的发生率。

 

 

      研究人员回顾性分析了 2016-2017年间接受腹腔镜手术(LDG)(n = 323)和腹腔镜保留幽门的胃切除术(LPPG)(n =144)的胃癌患者迷走神经的保存情况。胆囊结石的存在通过超声检查(US)和计算机断层扫描(CT)进行评估。比较神经保留(h-DG,h-PPG)组和切除迷走神经(s-DG,s-PPG)组的胆结石发生率。

 

 

      研究结果显示:h-DG的3年累积胆石发生率(2.7%,n = 85)低于s-DG组(14.6%, n  = 238)(p = 0.017),而h-PPG的胆石症发生率(1.6 %, n = 123)也比s-PPG(12.9%,  n  = 21)(p =0.004)明显要低。h-DG和s-DG之间的总体术后并发症发生率相似(p  = 0.861),h-PPG和s-PPG之间的总体术后并发症发生率相似(p = 0.768)。保留组和切除组的淋巴结站数目和3年无复发生存率无显着差异。迷走神经损伤(p  = 0.001)和高体重指数(BMI)(≥27.5kg /m2)(p  = 0.040)是多因素分析中胆结石形成的独立危险因素。

 

 

      因此,我们发现对于早期胃癌患者行LDG和LPPG后,建议保留迷走神经肝分支,以减少术后胆结石的形成。

 

 

原始出处:

Chao-Jie Wang. Et al. Preservation of hepatic branch of the vagus nerve reduces the risk of gallstone formation after gastrectomy. Gastric Cancer.2021.

 

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    2021-02-19 许安
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createdName=vera_1203, createdTime=Sat Apr 24 10:21:45 CST 2021, time=2021-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877365, encodeId=54c318e7365b9, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 02 01:21:45 CST 2021, time=2021-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893700, encodeId=5b071893e00b4, content=<a href='/topic/show?id=4fc4e85161' target=_blank style='color:#2F92EE;'>#gastric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7851, 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Wed Jan 13 08:21:45 CST 2021, time=2021-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915879, encodeId=75549158e980, content=<a href='/topic/show?id=02f31041183a' target=_blank style='color:#2F92EE;'>#保留迷走神经肝分支#</a><a href='/topic/show?id=67da104119e7' target=_blank style='color:#2F92EE;'>#胃切除术后胆结石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104118, encryptionId=02f31041183a, topicName=保留迷走神经肝分支), TopicDto(id=104119, encryptionId=67da104119e7, topicName=胃切除术后胆结石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Jan 12 12:41:30 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915847, encodeId=60b191584ede, content=好的,受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:20:24 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915700, encodeId=09df915e0046, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKz9YRd5PyUPf7dHLua5PK2yLib0USW6O80otjia8LDe1IAJzDGSEzhT2HEbdS4jPxkqU98fCndbY4w/132, createdBy=5a972363612, createdName=蛔虫, createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
    2021-08-04 skhzy
  5. [GetPortalCommentsPageByObjectIdResponse(id=2073217, encodeId=19ff20e3217d5, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 19 05:21:45 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921300, encodeId=371a19213000a, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Apr 24 10:21:45 CST 2021, time=2021-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877365, encodeId=54c318e7365b9, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 02 01:21:45 CST 2021, time=2021-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893700, encodeId=5b071893e00b4, content=<a href='/topic/show?id=4fc4e85161' target=_blank style='color:#2F92EE;'>#gastric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7851, 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Wed Jan 13 08:21:45 CST 2021, time=2021-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915879, encodeId=75549158e980, content=<a href='/topic/show?id=02f31041183a' target=_blank style='color:#2F92EE;'>#保留迷走神经肝分支#</a><a href='/topic/show?id=67da104119e7' target=_blank style='color:#2F92EE;'>#胃切除术后胆结石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104118, encryptionId=02f31041183a, topicName=保留迷走神经肝分支), TopicDto(id=104119, encryptionId=67da104119e7, topicName=胃切除术后胆结石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Jan 12 12:41:30 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915847, encodeId=60b191584ede, content=好的,受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:20:24 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915700, encodeId=09df915e0046, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKz9YRd5PyUPf7dHLua5PK2yLib0USW6O80otjia8LDe1IAJzDGSEzhT2HEbdS4jPxkqU98fCndbY4w/132, createdBy=5a972363612, createdName=蛔虫, createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2073217, encodeId=19ff20e3217d5, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 19 05:21:45 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921300, encodeId=371a19213000a, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, 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createdName=zb1235672, createdTime=Tue Jan 12 12:41:30 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915847, encodeId=60b191584ede, content=好的,受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:20:24 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915700, encodeId=09df915e0046, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKz9YRd5PyUPf7dHLua5PK2yLib0USW6O80otjia8LDe1IAJzDGSEzhT2HEbdS4jPxkqU98fCndbY4w/132, createdBy=5a972363612, createdName=蛔虫, createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
    2021-01-13 bshuang
  7. [GetPortalCommentsPageByObjectIdResponse(id=2073217, encodeId=19ff20e3217d5, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 19 05:21:45 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921300, encodeId=371a19213000a, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, 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  8. 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createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
    2021-01-12 ms5000001559080486

    好的,受教了

    0

  9. 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createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
    2021-01-11 蛔虫

    非常棒

    0

  10. 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createdTime=Mon Jan 11 22:21:40 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915688, encodeId=99d091568808, content=科学家厉害,造福人类!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58a15451937, createdName=健康是每个人的愿望, createdTime=Mon Jan 11 21:47:16 CST 2021, time=2021-01-11, status=1, ipAttribution=)]
    2021-01-11 健康是每个人的愿望

    科学家厉害,造福人类!!

    0

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Gastric Cancer:分泌型卷曲相关蛋白4(SFRP4)可促进胃癌的浸润并且是复发的早期预测指标

胃癌(GC)是全球第五大最常见的癌症,也是癌症相关死亡的第三大原因,在缺乏有效筛查检查的国家中,GC患者通常在被诊断时就是晚期阶段,因此导致了很高的相关死亡率。