Stroke:癌症患者再灌注治疗的中长期结局

2021-04-30 MedSci原创 MedSci原创

在活动性癌症患者中,再灌注疗法具有与其他组相似的不良事件和短期结局。尽管活动性癌症组的长期预后要比非活动性癌症组差,但仍有不少患者具有良好的功能预后,特别是那些卒中病因明确的患者。

急性卒中患者通常伴有合并症,例如活动性癌症。但是,这些患者没有足够的治疗指南建议。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在评估卒中患者癌症与再灌注治疗结局之间的关联。

研究人员使用全国性再灌注治疗登记中心,对接受再灌注治疗的患者的治疗效果进行了比较。研究人员根据癌症活动将患者分为三类:活动性癌症、非活动性癌症和无癌症史。研究人员调查了再灌注治疗后的再灌注过程、24小时神经系统改善情况、不良事件、3个月的功能结局、6个月的存活率和相关因素。

在接受再灌注治疗的1338例患者中,62例(4.6%)有活动性癌症,78例(5.8%)有非活动性癌症,1198例(89.5%)没有癌症史。在入组的患者中,969例患者接受了静脉溶栓治疗,685例患者接受了血管内治疗(316例接受了联合治疗)。活动性癌症患者合并症更多,卒中更为严重。

然而,与其他组相比,他们具有相似的24小时神经系统改善和不良事件,包括脑出血。尽管3个月时的功能结局较其他组差,但36.4%的活动性癌症患者表现出功能独立性。此外,尽管有活动性癌症,但在卒中病因明确的患者中,52.9%的患者表现出功能独立性。在6个月的随访中,46.6%的活动性癌症患者死亡,而活动性癌症与较低的存活率独立相关(风险比为3.973 [95%CI为2.528-6.245])。

由此可见,在活动性癌症患者中,再灌注疗法具有与其他组相似的不良事件和短期结局。尽管活动性癌症组的长期预后要比非活动性癌症组差,但仍有不少患者具有良好的功能预后,特别是那些卒中病因明确的患者

原始出处:

Joonsang Yoo.et al.Immediate and Long-Term Outcomes of Reperfusion Therapy in Patients With Cancer.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.032380

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1289712, encodeId=1d681289e12cf, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385130, encodeId=5c821385130f3, content=<a href='/topic/show?id=99d99e03311' target=_blank style='color:#2F92EE;'>#长期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97033, encryptionId=99d99e03311, topicName=长期结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489085, encodeId=4bc71489085ea, content=<a href='/topic/show?id=7b2130649c9' target=_blank style='color:#2F92EE;'>#再灌注治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30649, encryptionId=7b2130649c9, topicName=再灌注治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e33a8492666, createdName=xjy05, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961824, encodeId=4484961824f8, content=<a href='/topic/show?id=8e4616842bd' target=_blank style='color:#2F92EE;'>#Stroke#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16842, encryptionId=8e4616842bd, topicName=Stroke)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 16:52:18 CST 2021, time=2021-04-30, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1289712, encodeId=1d681289e12cf, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385130, encodeId=5c821385130f3, content=<a href='/topic/show?id=99d99e03311' target=_blank style='color:#2F92EE;'>#长期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97033, encryptionId=99d99e03311, topicName=长期结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489085, encodeId=4bc71489085ea, content=<a href='/topic/show?id=7b2130649c9' target=_blank style='color:#2F92EE;'>#再灌注治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30649, encryptionId=7b2130649c9, topicName=再灌注治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e33a8492666, createdName=xjy05, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961824, encodeId=4484961824f8, content=<a href='/topic/show?id=8e4616842bd' target=_blank style='color:#2F92EE;'>#Stroke#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16842, encryptionId=8e4616842bd, topicName=Stroke)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 16:52:18 CST 2021, time=2021-04-30, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1289712, encodeId=1d681289e12cf, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385130, encodeId=5c821385130f3, content=<a href='/topic/show?id=99d99e03311' target=_blank style='color:#2F92EE;'>#长期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97033, encryptionId=99d99e03311, topicName=长期结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489085, encodeId=4bc71489085ea, content=<a href='/topic/show?id=7b2130649c9' target=_blank style='color:#2F92EE;'>#再灌注治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30649, encryptionId=7b2130649c9, topicName=再灌注治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e33a8492666, createdName=xjy05, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961824, encodeId=4484961824f8, content=<a href='/topic/show?id=8e4616842bd' target=_blank style='color:#2F92EE;'>#Stroke#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16842, encryptionId=8e4616842bd, topicName=Stroke)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 16:52:18 CST 2021, time=2021-04-30, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1289712, encodeId=1d681289e12cf, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385130, encodeId=5c821385130f3, content=<a href='/topic/show?id=99d99e03311' target=_blank style='color:#2F92EE;'>#长期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97033, encryptionId=99d99e03311, topicName=长期结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489085, encodeId=4bc71489085ea, content=<a href='/topic/show?id=7b2130649c9' target=_blank style='color:#2F92EE;'>#再灌注治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30649, encryptionId=7b2130649c9, topicName=再灌注治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e33a8492666, createdName=xjy05, createdTime=Sun May 02 02:11:20 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961824, encodeId=4484961824f8, content=<a href='/topic/show?id=8e4616842bd' target=_blank style='color:#2F92EE;'>#Stroke#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16842, encryptionId=8e4616842bd, topicName=Stroke)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 16:52:18 CST 2021, time=2021-04-30, status=1, ipAttribution=)]
    2021-04-30 MedSciZeng

相关资讯

Ann Oncol:G-CSF+化疗可显著改善癌症患者的总生存期?

发表于《Ann Oncol》上的一项研究,考察了使用癌症化疗和粒细胞集落刺激因子(G-CSF)治疗恶性肿瘤,二次复发的总生存期和风险。

2019 AHA科学声明:癌症患者和生存者心脏-肿瘤康复管理心血管结局

2019年4月,美国心脏协会(AHA)发布了癌症患者和生存者心脏-肿瘤康复管理心血管结局的科学声明。心血管疾病是癌症患者早期死亡的竞争性原因,本文主要介绍了心脏肿瘤康复的相关内容,百科新功能不全的高危肿瘤患者的识别以及管理等。

癌症患者可以生孩子吗?对孩子有什么影响?

有时候,人生真的是挺残忍的,有的女性在怀孕期间,却被诊断为癌症,那么,这个时候,就陷入了纠结,到底这个孩子能不能要,那么,癌症患者可以生孩子吗?下面我们一起来了解一下吧。

2018 JSPM临床指南:癌症患者泌尿系统症状的治疗建议

2018年10月,日本姑息医学会(JSPM)发布了癌症患者泌尿系统症状的治疗建议指南,泌尿系统症状,例如肉眼血尿、上尿路症状以及膀胱疼痛常见于晚期癌症患者。本文总结了癌症患者出现泌尿系统症状的临床管理建议。

2019 AIOM/SIN共识意见:慢性肾病或血液透析的癌症患者的靶向治疗管理

2019年5月,意大利肿瘤医学协会(AIOM)联合意大利肾病学会(SIN)共同发布了慢性肾病或血液透析的癌症患者的靶向治疗管理共识。新型生物抗癌药物的出现明显改善了许多癌症患者的结局,但关于这些药物在慢性肾病和血液透析患者中的疗效、安全性以及药代动力学的数据有限,本文主要针对这类患者的靶向治疗管理提出共识意见。

JAMA Network Open:社交媒体招募癌症患者?或许时机尚早

根据2020年12月28日在线发表在《JAMA Network Open》(IF:5.03)上的一项调查结果,大多数癌症临床试验小组的研究人员基本上认为社交媒体可以为患者招募带来福音,但与此同时,人们