Diabetes Care:2型糖尿病患者抑郁障碍的终生持续时间分析

2016-12-18 MedSci MedSci原创

2型糖尿病(T2D)患者的抑郁症与长期并发症,残疾和早期死亡率有关。目前还没有研究系统地检查重症抑郁障碍(MDD)和T2D成人患者的抑郁症发病持续时间和缓解的情况。这项研究探讨了T2D和MDD患者抑郁症的过程。研究人员纳入了50名T2D和MDD成人参与者参加了一项行为干预研究,采用DSM-IV-TR结构化临床面试采访评估了基线,干预后和3个月随访的抑郁症病史。研究人员记录了从出生到最后面试的所有A

2型糖尿病(T2D)患者的抑郁症与长期并发症,残疾和早期死亡率有关。目前还没有研究系统地检查重症抑郁障碍(MDD)和T2D成人患者的抑郁症发病持续时间和缓解的情况,此项研究探讨了T2D和MDD患者抑郁症的过程。

研究人员纳入了50名T2D和MDD成人参与者参加了一项行为干预研究,采用DSM-IV-TR结构化临床面试采访评估了基线,干预后和3个月随访的抑郁症病史。研究人员记录了从出生到最后面试的所有Axis I抑郁障碍的开始和缓解日期。

MDD发作的平均数为1.8次,平均持续时间为23.4个月(SD 31.9;范围0.5-231.3)。在整个生命过程中,MDD的平均暴露时间为43.1个月(SD 46.5;范围0.5-231.3)。Kaplan-Meier存活曲线分析表明平均发作持续时间在随后的发作中会减少(第一次发作14个月;第二次发作9个月;P<0.002)。在多次抑郁发作的患者中,随后每次发作的恢复时间都较短(P=0.002)。基于T2D诊断的年表,抑郁症发作或缓解的时间没有差异。

T2D成人患者相当长时间暴露于抑郁可能会导致消极的医疗和精神结果,但后期的复发时间和随后的恢复期都会减少。这项研究的结果强调需要有效诊断和治疗T2D患者的抑郁症,以最大限度减少未来抑郁发作的风险。

原始出处:

Mary de Groot,Kent A. Crick,Molly Long,et al. Lifetime Duration of Depressive Disorders in Patients With Type 2 Diabetes. Diabetes Care.2016 Dec.

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