JCO:电话心理咨询可改善宫颈癌患者的生活质量

2015-02-28 Jessie 译 MedSci原创

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宫颈癌存活者在完成治疗后数年,生活质量仍存在不足。近期,加州大学欧文分校的研究者在JCO杂志上报道了他们的一项关于心理社会电话咨询(psychosocial telephone counselingPTC)干预对宫颈癌存活者生活质量和部分生物学指标影响的研究结果。
 
该研究运用随机对照的实验设计,招募了204名宫颈癌患者,患者的诊断时间在9个月及以上30个月以内。将这些患者随机分为两组,一组接受PTC干预,另一组接受常规护理。PTC包括为期5周每周一次的电话心理咨询及为期一个月的支持期。分别在基线、开始干预后的4个月和9个月评估患者自我报告的结局变量(焦虑、抑郁、妇科相关的担忧、癌症相关的担忧等),并收集生物样本检测其中的细胞因子水平。主要的分析方法是多变量重复测量方差分析,用来比较不同时间点结局变量的差异及与细胞因子的关系。
 
患者的平均年龄为43岁,其中40%为西班牙裔,51%为非西班牙裔白人。控制了患者的年龄和基线时的结局变量水平,4个月时接受PTC的患者的抑郁、妇科及癌症相关的担忧较接受常规护理的患者有显著的改善(P0.05)。9个月时接受PTC的患者的妇科及癌症相关的担忧仍低于接受常规护理的对照组(P0.05)。PTC干预前后生活质量和焦虑水平的变化没有达到统计学意义。细胞因子方面,IL-4IL-5IL-10IL-13降低的患者与升高的患者相比,生活质量显著改善。
 
结论:本研究证实PTC干预对宫颈癌存活者的情绪、生活质量及妇科和癌症相关的担忧具有改善作用。细胞因子降低与结局变量的改善有关,提示癌症存活者可能存在着与癌症有关的生物行为学通路。
 
原始出处:

Wenzel L, Osann K, Hsieh S, Tucker JA, Monk BJ, Nelson EL. Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial. J Clin Oncol. 2015 Feb 23. pii: JCO.2014.57.4079. [Epub ahead of print]

本文是MedSci编译,欢迎转载,转载请注明出处,非常感谢!
 

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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2015-05-16 ljjj1053

    很不错学习了

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1068513, encodeId=84561068513b9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:38:17 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659790, encodeId=20061659e90cc, content=<a href='/topic/show?id=ba7d5114062' target=_blank style='color:#2F92EE;'>#心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51140, encryptionId=ba7d5114062, topicName=心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0cf25034369, createdName=zxl737, createdTime=Wed Apr 22 23:58:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23725, encodeId=73c423e2572, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798739, encodeId=8e3c1e9873975, content=<a href='/topic/show?id=2e23e01742a' target=_blank style='color:#2F92EE;'>#电话心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70174, encryptionId=2e23e01742a, topicName=电话心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Wed Jan 06 15:58:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891176, encodeId=c93e18911e654, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Fri Nov 06 15:58:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407944, encodeId=f1c0140e9448c, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Mon Mar 02 06:58:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17269, encodeId=c5e71e26949, content=不错,给了一定的课题启发, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat Feb 28 20:16:00 CST 2015, time=2015-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17256, encodeId=81f01e25647, content=沟通重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Feb 28 19:35:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
    2015-11-06 lidong40
  6. [GetPortalCommentsPageByObjectIdResponse(id=1068513, encodeId=84561068513b9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:38:17 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659790, encodeId=20061659e90cc, content=<a href='/topic/show?id=ba7d5114062' target=_blank style='color:#2F92EE;'>#心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51140, encryptionId=ba7d5114062, topicName=心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0cf25034369, createdName=zxl737, createdTime=Wed Apr 22 23:58:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23725, encodeId=73c423e2572, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798739, encodeId=8e3c1e9873975, content=<a href='/topic/show?id=2e23e01742a' target=_blank style='color:#2F92EE;'>#电话心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70174, encryptionId=2e23e01742a, topicName=电话心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Wed Jan 06 15:58:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891176, encodeId=c93e18911e654, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Fri Nov 06 15:58:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407944, encodeId=f1c0140e9448c, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Mon Mar 02 06:58:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17269, encodeId=c5e71e26949, content=不错,给了一定的课题启发, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat Feb 28 20:16:00 CST 2015, time=2015-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17256, encodeId=81f01e25647, content=沟通重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Feb 28 19:35:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
    2015-03-02 一闲
  7. [GetPortalCommentsPageByObjectIdResponse(id=1068513, encodeId=84561068513b9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:38:17 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659790, encodeId=20061659e90cc, content=<a href='/topic/show?id=ba7d5114062' target=_blank style='color:#2F92EE;'>#心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51140, encryptionId=ba7d5114062, topicName=心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0cf25034369, createdName=zxl737, createdTime=Wed Apr 22 23:58:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23725, encodeId=73c423e2572, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798739, encodeId=8e3c1e9873975, content=<a href='/topic/show?id=2e23e01742a' target=_blank style='color:#2F92EE;'>#电话心理咨询#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70174, encryptionId=2e23e01742a, topicName=电话心理咨询)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Wed Jan 06 15:58:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891176, encodeId=c93e18911e654, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Fri Nov 06 15:58:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407944, encodeId=f1c0140e9448c, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Mon Mar 02 06:58:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17269, encodeId=c5e71e26949, content=不错,给了一定的课题启发, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat Feb 28 20:16:00 CST 2015, time=2015-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17256, encodeId=81f01e25647, content=沟通重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Feb 28 19:35:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
    2015-02-28 zhouanxiu

    不错,给了一定的课题启发

    0

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    2015-02-28 medcardio

    沟通重要!

    0

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