Nutrients:低蛋白饮食的慢性肾病患者肠道菌群及代谢的适应性变化

2021-04-09 MedSci原创 MedSci原创

中晚期慢性肾脏病(CKD)患者普遍推荐饮食蛋白限制,然而低蛋白饮食(LPD,<0.8g/kg体重/天)对维护肾功能的有效性仍存在争议。饮食结构会影响肠道微生物群,不良的饮食结构可能会导致代谢紊乱

中晚期慢性肾脏病(CKD)患者普遍推荐饮食蛋白限制,然而低蛋白饮食(LPD,<0.8g/kg体重/天)对维护肾功能的有效性仍存在争议。饮食结构会影响肠道微生物群,不良的饮食结构可能会导致代谢紊乱。既往研究发现,低蛋白饮食与肠道菌群中特定微生物的丰度变化有关,然而这些微生物的功能,以及继发于肠道微生物群的这种适应性变化仍不清楚。近日,研究人员通过粪便16S rRNA基因测序和血清代谢组学分析,揭示了肠道微生物群的变化与低蛋白饮食(LPD)相关的宿主血清代谢组学之间的关系,研究结果已发表于Nutrients。

结果显示,LPD的CKD患者肠道微生物群β多样性发生显著变化(CKD-LPD,n = 16)。CKD-LPD患者肠道微生物菌群中19个属和12个物种的相对丰度与接受正常蛋白饮食的患者(CKD-NPD,n = 27)或非CKD对照组(n = 34)均有显著差异。

CKD-LPD患者肠道菌群中许多丁酸盐生产菌(毛螺菌科和拟杆菌科)的丰度显著降低,与丁酸盐代谢功能模块的富集有关,导致血清中SCFA(乙酸、庚酸和壬酸)的水平随之降低。然而,在CKD-LPD患者中,一种次生胆汁酸--乙二醇λ-穆里奇酸的水平显著增加。各组间血清中硫酸吲哚基和硫酸对甲酚基的水平无差异。

 

在重采样受试者子集中,微生物的丰度与代谢物的关系仍然密切。在CKD-LPD患者中,研究人员发现与D-丙氨酸、酮体和谷胱甘肽代谢相关的细菌基因标记物的富集。

综上所述,该研究分析揭示了肠道微生物群适应肾脏患者饮食蛋白限制的标志物和功能。

 

原始出处:

 

I-Wen Wu, et al., Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction. Nutrients. 2020 Sep 12;12(9):2799. doi: 10.3390/nu12092799.

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    2021-06-15 12192b1am98暂无昵称

    学习了

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