JAHA:合并症可解释创伤后应激障碍与心血管疾病的关系

2019-02-13 xing.T MedSci原创

由此可见,PTSD不是CVD的独立危险因素。与PTSD共同发生的身体和精神疾病以及吸烟解释了为什么这个患者群体患CVD的风险增加。仔细监测可能会受限于接触的CVD危险因素和随后的CVD事件。

创伤后应激障碍(PTSD)与血管疾病(CVD)的风险相关。与PTSD相关的生物心理社会因素可能是这种关联的部分或全部原因。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在确定1个或合并症的组合是否解释了PTSD与CVD事件之间的关联。

研究人员使用分布在美国各地的5个退伍军人健康事务医疗中心中符合条件的患者。数据来自电子健康记录,在索引日期,2519名退伍军人健康事务(VA)患者,30至70岁,有创伤后应激障碍,1659名参与者没有。这些患者在索引日期前12个月没有CVD诊断。患者可以在2008年至2012年之间进入队列,随访至2015年。在调整合并症之前和之后计算年龄校正的Cox比例风险模型。

患者为中年(平均=50.1岁,SD为±11.0),多为男性(87.0%),60%为白人。PTSD与CVD事件之间年龄调整的关联是显著的(风险比=1.41; 95%CI为1.21-1.63)。在调整代谢性疾病后,PTSD与CVD事件之间的关联有所减弱但仍然显著(风险比=1.23; 95%CI为1.06-1.44)。在对吸烟、睡眠障碍、药物使用障碍、焦虑症和抑郁症进行额外调整后,PTSD与CVD事件无关(风险比=0.96; 95%CI为0.81-1.15)。

由此可见,PTSD不是CVD的独立危险因素。与PTSD共同发生的身体和精神疾病以及吸烟解释了为什么这个患者群体患CVD的风险增加。仔细监测可能会受限于接触的CVD危险因素和随后的CVD事件。

原始出处:

Jeffrey F. Scherrer.et al.Comorbid Conditions Explain the Association Between Posttraumatic Stress Disorder and Incident Cardiovascular Disease.JAHA.2019.https://www.ahajournals.org/doi/10.1161/JAHA.118.011133

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    2019-02-15 zhaohui6731
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1825862, encodeId=f9fd182586209, content=<a href='/topic/show?id=c52d388137b' target=_blank style='color:#2F92EE;'>#合并症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38813, encryptionId=c52d388137b, topicName=合并症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Nov 23 15:38:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268054, encodeId=f48812680544b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Feb 15 10:38:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335242, encodeId=1b0b133524224, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri Feb 15 10:38:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445268, encodeId=a957144526837, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79df5138909, createdName=ms1260584454294838, createdTime=Fri Feb 15 10:38:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498535, encodeId=1b40149853572, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Feb 15 10:38:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360565, encodeId=886a360565f5, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Feb 13 19:53:00 CST 2019, time=2019-02-13, status=1, ipAttribution=)]
    2019-02-13 一个字-牛

    学习了谢谢分享

    0