Clinical Nutrition:加工肉的摄入量与结直肠癌的风险相关

2021-06-18 MedSci原创 MedSci原创

加工肉类和高钠摄入在西方饮食中很常见,什么是加工肉类,国际癌症研究机构是这样解释的:所有经过熏、腌、风干或用其他方式处理的为了增加风味以及长久保存的肉类。

      加工肉类和高钠摄入在西方饮食中很常见,什么是加工肉类,国际癌症研究机构是这样解释的:所有经过熏、腌、风干或用其他方式处理的为了增加风味以及长久保存的肉类。加工肉类为什么容易致癌呢?一是因为它们的制作过程(盐渍、烟熏)会产生较多的亚硝酸盐,长期大量食用加工肉类,的确会增加患上大肠癌的风险。本项研究旨在对加工肉类对结直肠癌 (CRC) 风险的独立影响进行分析。

 

      研究人员对所纳入的受试者进行了观察分析,并使用孟德尔随机化 (MR) 进行了遗传分析。通过多变量 Cox 比例风险模型将 24 小时尿钠 (UNa) 和加工肉类摄入量拟合到事件 CRC的发生率中,并针对协变量进行调整,例如年龄、性别、家族史等。

 

      本项研究共纳入415524 名符合条件的参与者。在中位随访 11.1 年期间,2663 名参与者被诊断出患有 CRC。大量摄入加工肉会使 CRC 风险增加 23%(HR 1.23;95% CI:1.03 至 1.46),但 24 小时钠摄入水平与 CRC 无显着相关性(HR 0.96;95% CI:0.87 至 1.06)。

 

      本项研究证实加工肉类的摄入量对 CRC 的风险有独立影响,但CRC风险与钠水平无关。减少加工肉类的摄入量可能是预防 CRC 的有效策略。

 

 

原始出处:

Qi Feng. Et al. Intake of processed meat, but not sodium, is associated with risk of colorectal cancer: evidence from a large prospective cohort and two-sample Mendelian randomization. Clinical Nutrition.2021.

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    2022-05-01 lmm397
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    2021-06-20 zll0628
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    2021-06-18 ms5000002087413465

    新年

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