Stroke:大面积脑梗死也能从再灌注治疗中获益

2018-04-17 杨中华 脑血管病及重症文献导读

血管内血栓切除术(MT)是大动脉闭塞性急性缺血性卒中的标准治疗方案。但是大面积梗死者MT治疗的有效性还不清楚,以前的研究都把这些患者排除在外。

血管血栓切除术(MT)是大动脉闭塞性急性缺血性卒中的标准治疗方案。但是大面积梗死者MT治疗的有效性还不清楚,以前的研究都把这些患者排除在外。

THRACE试验是法国多中心随机试验,探讨了近端大动脉闭塞性急性缺血性卒中静脉溶栓联合MT(vs 单纯静脉溶栓)的有效性。在该研究中有57例患者基线ASPECTS评分<5。有意思的是其中17例患者3个月预后良好(mRS>=2),提示这些患者也能从再灌注治疗中获益,这与以前的研究结果是一致的。DWI缺血病灶的体积比ASPECTS评分更加精确。

2018年3月来自法国的Vincent Gautheron等在Stroke上公布了他们的研究结果。他们利用THRACE试验的数据,探讨了基线DWI>= 70ml的患者基线参数与预后之间的关系。

DWI >=70ml者共53例,3个月时12例预后良好(mRS<=2);与mRS>2者相比,mRS<=2者合并冠心病比例更低(0/12 versus 12/38; P=0.046),抽烟病史者更少(1/10 versus 12/31; P=0.013)。8例年龄>75岁的患者没有一例达到mRS<=2。M1段闭塞者良好预后的比例是12/37,颈内-T/L-闭塞者良好预后的比例是0/16(P = 0.01)。与MCA深部DWI病灶(6/40)相比,MCA表浅DWI病灶(6/13)预后更佳,P = 0.5。

最终作者认为DWI>70ml者也能从再灌注治疗中获益,特别是孤立M1段闭塞或缺血局限于MCA表浅区域者。颈动脉闭塞或累及MCA深部区域者获益不明显。

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    2018-08-08 仁医06
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    2018-04-19 karmond
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    2018-04-17 虈亣靌

    不错.学习了.谢谢分享

    0

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