内分泌

订阅

MedSci主页 / 所有栏目 / 内分泌

我就看看我不吃？NO！Cell子刊：仅看一眼食物，就能引发脑内炎症因子分泌

2022-07-11 四五七 MedSci原创

炎症因子胰岛β细胞血糖变化
关注

Cell Metabolism：食物刺激引起大脑炎症因子短暂增加，进而激活支配胰腺的副交感神经，在食物还未引起血糖变化前，就促使胰岛β细胞提前释放胰岛素，对降低餐后血糖、维持血糖稳态起着重要作用。

闻到食物的香气，看见烤肉滋滋冒油，甚至仅在脑海想象，就能调动我们身体一系列的反应，正如古人望梅止渴，想起梅子酸甜的滋味，不禁分泌口水。
不过，最近科学家有了新发现，那就是——食物对视觉、味觉、嗅觉的刺激以及咀嚼食物产生的感觉（本体觉）竟然会引起脑内炎症因子释放增加。
“炎症因子释放增加”，乍一听就不像什么好事，那不是说明美食当前，我们连看一看、闻一闻、脑海里想象一下都不行了？
诶，先别急着下定论！
实际上这篇研究讲的是：食物刺激引起大脑炎症因子短暂增加，进而激活支配胰腺的副交感神经，在食物还未引起血糖变化前，就促使胰岛β细胞提前释放胰岛素，对降低餐后血糖、维持血糖稳态起着重要作用。也就是说，脑内的炎症因子参与调控了胰岛素的释放。该研究发表于Cell Metabolism。
图片
在食物进入消化系统分解产生营养物质，引起血糖变化前，食物对视、味、嗅、本体觉等感觉的刺激，就能引发胰岛素释放，称为“头相胰岛素释放（cephalic phase insulin release）”，这一过程在食物刺激2-4分钟后发生，并且在不摄入食物的情况下还能持续8-10分钟。
禁食过夜的小鼠吃下第一口食物后（模拟食物对感觉的刺激），迅速将小鼠取出笼子进行采血，尽管此时小鼠血糖水平并未发生变化，但是胰岛素水平却明显上升，但如果是面对大小、形状与食物相似的橡胶塞，小鼠则不会发生血液胰岛素水平升高，说明只有真正的食物刺激，才能诱发“头相胰岛素反应”。
图片
“头相胰岛素释放”有多重要呢，和没有经历过“头相胰岛素释放”的对照组小鼠相比，经历了“头相胰岛素释放”的小鼠，在口服糖耐量试验中分泌的胰岛素更多，葡萄糖耐量更好。
即使在口服糖耐量试验前给小鼠静脉注射小剂量胰岛素，也不能做到像 “头相胰岛素释放”一样改善小鼠葡萄糖耐量，说明“头相胰岛素释放”不仅在早期促进胰岛素分泌，还对餐后血糖稳态起到一个整体调控的作用。
图片
胰岛素的释放受到副交感神经支配，三种副交感神经阻断药物（毒蕈碱受体拮抗剂），只有能够穿过血脑屏障的阿托品作用之后，“头相胰岛素释放”才被抑制，提示“头相胰岛素释放”需要中枢神经的参与。
图片
涉及到中枢神经系统，研究人员就发现，给小鼠喂食后，小鼠脑内小胶质细胞炎症因子IL-1β基因表达迅速上升，特别是在负责调节摄食行为的下丘脑区域，此前也有研究表明，食物摄入会使得髓样细胞产生IL-1β，促进餐后胰岛素分泌，但这一过程是如何发生的，机制并不明确。
向小鼠脑脊液注射IL-1β后进行糖耐量试验，小鼠胰岛素分泌显著增多，葡萄糖耐量明显改善；反之，向小鼠脑脊液中注射IL-1β拮抗剂，小鼠“头相胰岛素分泌”减少，进一步实验中，特异性敲除小鼠脑内小胶质细胞的IL-1β基因（Cx3cr1-CreERT2 Il1bfl/fl），同样能观察到小鼠“头相胰岛素分泌”受损，以上实验说明小胶质细胞分泌的IL-1β是促进“头相胰岛素分泌”的关键。
图片
不过，脑内的炎症因子并不是越多越好，肥胖人群长期处于慢性炎症状态，过量的炎症因子释放，反而抑制了他们的“头相胰岛素反应”，这点在高脂饮食喂养2周的小鼠身上也可以看到——食物的刺激并不能使高脂饮食的小鼠早期胰岛素分泌增加，相反，只有向小鼠注射IL-1β拮抗剂，才能维持小鼠“头相胰岛素分泌”。
由此看来，肥胖导致的炎症因子分泌过多还会扰乱“头相胰岛素分泌”，要想预防这一结局发生，还得是IL-1β拮抗剂来平衡，说明适量的炎症因子才能调动“头相胰岛素分泌”。
图片
一直以来科学家对于食物对感觉的刺激是如何在短短几分钟内就诱发胰岛素分泌，甚至是在血糖变化前，而感到疑惑，如今终于补上了关键的一环，即脑内小胶质细胞分泌的IL-1β在“头相胰岛素分泌”的调控中发挥重要作用。
能不能闻一闻、看一看、想象一下美食？对于瘦子来说，当然可以，甚至还能充分调动“头相胰岛素分泌”，有利于餐后血糖稳态的控制。
对于胖子来说，则是少闻、少看、少想，脑内炎症因子已经够多了，该考虑的是如何减肥，降低炎症反应！

 

参考文献：

[1]Wiedemann SJ, Trimigliozzi K, Dror E, et al. The cephalic phase of insulin release is modulated by IL-1β. Cell Metab. 2022;34(7):991-1003.e6. doi:10.1016/j.cmet.2022.06.001

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-08-09 zhaozhouchifen

    #Cell#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-08-20 gwc392

    #分泌#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-12-28 维他命

    #CEL#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-07-12 yhy100201

    #食物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-07-11 屋顶瞄爱赏月

    签到学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1872462, encodeId=28af18e2462a3, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Aug 09 00:43:40 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682738, encodeId=0f361682e384d, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Aug 20 06:43:40 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962790, encodeId=c1931962e90b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 28 18:43:40 CST 2022, time=2022-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416935, encodeId=edb41416935df, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 12 14:43:40 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231731, encodeId=9c311231e310c, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Mon Jul 11 08:45:51 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231727, encodeId=499c1231e271a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrZ5ib9TDTscB1VwxFIOnQEBScQ5rKcjx3icreb8nejzpkyp89lnwjka375d3kBFfHbmOEpJfZ0dAX/0, createdBy=a5731963692, createdName=wamgel2, createdTime=Mon Jul 11 08:30:52 CST 2022, time=2022-07-11, status=1, ipAttribution=)]
    2022-07-11 wamgel2

    学习了

    0

相关资讯

Nat Neurosci： 阿尔兹海默病中，PLCγ2介导小胶质细胞炎症作用

研究人员使用基因工程的人类诱导多能干细胞衍生的小胶质细胞样细胞发现，TREM2通过PLCγ2信号来介导细胞存活、吞噬能力、神经元碎片的处理和脂质代谢。

Clin Oral Investig：牙周支持疗法过程中龈沟液的细胞因子水平

这篇研究的目的是为了长效评估牙周支持疗法(PMT)期间的依从性对细胞因子水平和它们与牙周状态之间关系的影响。

Clin Exp Pharmacol Physiol：淫羊藿苷能够抑制组胺诱导的鼻粘膜上皮细胞炎症细胞因子和粘蛋白的表达

过敏性鼻炎（AR）是一种呼吸道疾病，并且与慢性炎症相关。淫羊藿苷是一种天然香豆素衍生物，并且报道具有抗过敏和抗炎症作用。然而，淫羊藿苷在AR中的作用还没有研究。最近，有研究人员调查了淫羊藿苷对AR的影响。研究人员利用组胺对淫羊藿苷预处理过或者没有预处理过的人类鼻上皮细胞（HNEpC）进行持续24小时的刺激，并利用qRT-PCR和ELISA定量了相关细胞因子的mRNA水平和蛋白水平。研究发现，淫羊藿

GUT：围手术期低血浆VD水平与CRC不良预后相关

研究发现，CRC手术后循环中25OHD下降。血浆25OHD水平是一个预后生物标志物，低25OHD与不良预后相关，特别是在rs11568820 GG基因型患者中

J Periodontal Res：牙周健康和疾病患者中唾液Del-1, IL-17和LFA-1的水平分析

在牙周疾病中，Developmental endothelial locus-1 (Del-1)， lymphocyte function-associated antigen-1 (LFA-1)和i

J Periodontal Res：健康和牙周炎患者唾液及龈沟液中可溶性Urokinase Plasminogen Activator Receptor (suPAR), galectin-1和TNF-α表达水平评估

水溶性urokinase plasminogen activator receptor (suPAR)被认为是炎症反应和免疫活性的生物标记物。Galectin-1为半乳凝素家族的成员之一，是一种抗炎症