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Heart：增加的血管内皮生长因子D与房颤和缺血性卒中有关

2018-10-17 xing.T MedSci原创

VEGF-D房颤缺血性卒中
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由此可见，VEGF-D浓度升高与AF和缺血性卒中有关。在诊断为房颤的受试者中，与缺血性卒中的关系更为明显。

血管内皮生长因子D（VEGF-D）在淋巴管生成和血管生成中具有重要功能。血浆中高水平的VEGF-D与心力衰竭的发生率有关。VEGF-D与房颤（AF）和卒中之间的关系尚不清楚，近日，心脏病领域权威杂志Heart上发表了一篇研究文章，研究人员假设VEGF-D也可能与AF和缺血性卒中的发生有关。

在马尔默饮食和癌症研究（一项在瑞典进行的一项基于人群的前瞻性研究）中，研究人员对4689例（40％男性）受试者空腹血液样本中的VEGF-D进行了测量，这些患者没有房颤病史。中位年龄为58岁（范围为46-68）。针对多种危险因素调整后的Cox回归分析用于评估与VEGF-D水平相关的AF和缺血性卒中风险。

在中位随访时间20.6期间，共发生637例AF事件和322例首次缺血性卒中。调整后，VEGF-D与AF（每增加一个SD的HR为1.13（95％CI为1.04至1.23））和缺血性卒中（每增加一个SD的HR为1.14（95％CI为1.02至1.28））显著相关。其与缺血性卒中的关系可通过AF相关卒中的发病率增加来解释。每增加一个SD发生AF相关缺血性卒中的HR为1.34（95％CI为1.04-1.71），发生无AF相关缺血性卒中的HR为1.04（95％CI为0.90-1.19）。

由此可见，VEGF-D浓度升高与AF和缺血性卒中有关。在诊断为房颤的受试者中，与缺血性卒中的关系更为明显。

原始出处：

John Berntsson.et al. Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke.Heart. 2018. http://dx.doi.org/10.1136/heartjnl-2018-313684

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    2018-10-24 guihongzh

    #缺血性#

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    2018-11-16 12498da4m32(暂无昵称)

    #缺血性卒#

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    2018-10-19 zhaojie88

    #ART#

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    2018-10-19 12499e01m50暂无昵称

    #生长因子#

    0

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    2018-10-19 slcumt

    #HEART#

    0

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    2018-10-19 qilu_qi

    #血管内皮生长因子#

    0

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    2018-10-17 健健

    卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

    0

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