Microb Pathog:在牙周健康个体和慢性牙周炎患者中通过ELISA检测血清和唾液中的伴放线聚集杆菌的水平

2018-10-14 MedSci MedSci原创

牙周炎是持续的多微生物感染,导致牙齿支持组织中的慢性炎症。伴放线聚集杆菌是口腔的正常菌体,但在牙周健康受试者中数量较少,是与牙周病病原学相关的主要病原体之一。血浆和唾液抗体测量可用于支持牙周炎的诊断、疾病活动、分类和预后。本研究旨在调查血清和唾液抗体水平与伴放线聚集杆菌之间的关联,因此,找出这种关联是否在不同级别的牙周炎中有所不同。 研究共纳入了50名牙周健康和50名慢性牙周炎受试者(35-

牙周炎是持续的多微生物感染,导致牙齿支持组织中的慢性炎症。伴放线聚集杆菌是口腔的正常菌体,但在牙周健康受试者中数量较少,是与牙周病病原学相关的主要病原体之一。血浆和唾液抗体测量可用于支持牙周炎的诊断、疾病活动、分类和预后。本研究旨在调查血清和唾液抗体水平与伴放线聚集杆菌之间的关联,因此,找出这种关联是否在不同级别的牙周炎中有所不同。

研究共纳入了50名牙周健康和50名慢性牙周炎受试者(35-65岁)。在无菌条件下收集2ml未刺激的唾液和5ml的静脉血。使用间接ELISA检测牙周健康个体和患有慢性牙周炎的个体中针对放线杆菌的抗体。

结果显示,与牙周健康受试者的平均水平相比,慢性牙周炎受试者中放线杆菌的血清IgG,IgA平均水平更高。类似地,与健康受试者相比,慢性牙周炎患者中的唾液IgG,IgA水平也升高。随着疾病严重程度的增加,血清IgG和唾液IgA的平均水平也增加。

总之,该研究结果表明,使用唾液和血清的抗体滴度可以用于筛选慢性牙周炎患者。此外,使用唾液监测治疗结果的各个阶段可能是一个有用的、非侵入性的预后指标。

原始出处:

Gadekar NB, Hosmani JV, et al., Detection of antibodies against Aggregatibacter actinomycetemcomitans in serum and saliva through ELISA in periodontally healthy individuals and individuals with chronic periodontitis. Microb Pathog. 2018 Oct 9. pii: S0882-4010(18)30874-X. doi: 10.1016/j.micpath.2018.10.007. 

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    2018-10-20 phoebeyan520

    学习了

    0

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    2018-10-15 明月清辉

    谢谢分享,学习了

    0