Public Health Nutr:欧洲癌症和营养前瞻性调查(EPIC)中膳食摄入叶酸当量和心肌梗塞的风险

2019-08-28 sunshine 译 MedSci原创

目的:评估德国队列中膳食叶酸当量摄入与心肌梗死风险之间的关系。设计:通过经验证的食物频率问卷评估摄入的膳食叶酸当量。使用Cox比例风险模型评估膳食叶酸当量的摄入与心肌梗塞风险之间的关联。设置:欧洲癌症和营养前瞻性调查(EPIC) - 波茨坦队列,德国。受试者:纳入22,245名非常健康的受试者,未使用维生素补充剂,年龄为35-64岁。结果:在4.6年的随访期间,确定了129例心肌梗死事件。与摄入量

目的:
评估德国队列中膳食叶酸当量摄入与心肌梗死风险之间的关系。

设计:
通过经验证的食物频率问卷评估摄入的膳食叶酸当量。使用Cox比例风险模型评估膳食叶酸当量的摄入与心肌梗塞风险之间的关联。

设置:
欧洲癌症和营养前瞻性调查(EPIC) - 波茨坦队列,德国。

受试者:
纳入22,245名非常健康的受试者,未使用维生素补充剂,年龄为35-64岁。

结果:
在4.6年的随访期间,确定了129例心肌梗死事件。与摄入量低于中位数(103微克)相比,摄入更多的膳食叶酸当量与多变量调校正风险比(HR)0.57(95%置信区间(CI)0.36-0.91)相关。乙醇摄入量等于或高于性别中位数(HR = 0.37,95%CI 0.18-0.79)的参与者叶酸摄入量与心肌梗死风险呈更强的负相关,而乙醇摄入量低的患者这种关联较弱(HR= 0.67,95%CI 0.37-1.22)。

结论:
膳食叶酸当量的摄入增加与德国研究人群中心肌梗塞的风险降低相关,指出叶酸摄入对心肌梗塞一级预防的重要性。

原始出处:

Drogan D, Klipstein-Grobusch K, et al., Dietary intake of folate equivalents and risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition (EPIC)--Potsdam study. Public Health Nutr. 2006 Jun;9(4):465-71.

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    2019-08-30 zhaojie88
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    2020-07-08 shizhenshan