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GUT：粪便血红蛋白阳性与多种疾病死亡风险增加相关

2018-07-19 zhangfan MedSci原创

粪便血红蛋白CRC结肠癌
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可检测的粪便血红蛋白与多种疾病死亡风险增加相关

一般认为可检测的粪便血红蛋白(f-Hb)与结直肠癌(CRC)和全因死亡风险之间存在关联。近日研究人员在英国患者队列研究中验证愈伤组织粪便潜血试验（GFOBT）结果阳性与结肠癌死亡之间的关联。

2000-16年间，134192名gFOBT筛查人群参与研究，记录参与者筛查结果并考察结果与参与者死亡之间的关系。

总计2714名参与者筛查结果为阳性，相对于阴性人群，在调整性别、年龄以及药物出血因素后，阳性人群的CRC死亡（HR=7.79）以及非CRC死亡（HR=1.58）风险增加， p<0.0001。此外gFOBT检测法f-Hb阳性人群的循环系统、呼吸系统、消化系统疾病(不包括CRC)、神经心理疾病、血液和内分泌疾病以及非CRC疾病死亡风险增加。

研究发现，可检测的粪便血红蛋白与多种疾病死亡风险增加相关。

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-08-05 青山颖钰

    学习了

    0

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    2018-07-27 GZphD9

    学习了

    0

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    2018-07-20 psybestwish

    #粪便血红蛋白#

    0

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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-07-20 Homburg

    #粪便#

    0

  5. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-07-20 huangdf

    #便血#

    0

  6. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-20 quxin068

    #死亡风险#

    0

  7. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 Jackie Li

    学习

    0

  8. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 明崖

    学习下，有用的研究

    0

  9. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 牛顿爱吃苹果

    学习了

    0

  10. 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encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 20 21:24:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332730, encodeId=3b37332e30f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Jul 19 14:21:36 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332701, encodeId=bc02332e0133, content=学习下，有用的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Thu Jul 19 12:34:19 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332698, encodeId=b4e23326988f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230214/f9a4c33015ad4f8c8421eeb2fef26ab3/8f194fc039fc48afa071caaab4eff3ab.jpg, createdBy=98072077561, createdName=牛顿爱吃苹果, createdTime=Thu Jul 19 12:00:26 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332695, encodeId=a76233269550, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3c485caee58448a74e2f8e0e8cd4a710.jpg, createdBy=f4421981394, createdName=lary, createdTime=Thu Jul 19 11:47:19 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-19 lary

    学习了

    0

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