Nutrients:基于杏仁的低碳水化合物饮食可改善2型糖尿病患者的抑郁和糖代谢情况

2021-04-19 MedSci原创 MedSci原创

低碳水化合物饮食(LCD)有益于2型糖尿病(T2DM)的糖代谢,可有效降低抑郁症。杏仁是一种常见的坚果,能有效改善机体的高血糖和抑郁症状。近日,一项随机对照试验探究了基于杏仁的LCD(a-LCD)对T

低碳水化合物饮食(LCD)有益于2型糖尿病(T2DM)的糖代谢,可有效降低抑郁症。杏仁是一种常见的坚果,能有效改善机体的高血糖和抑郁症状。近日,一项随机对照试验探究了基于杏仁的LCD(a-LCD)对T2DM患者抑郁和糖代谢,以及肠道微生物群和空腹胰岛素样肽1(GLP-1)的影响,研究结果已发表于Nutrients。

2018年12月至2019年12月期间,研究纳入了45名T2DM参与者,完成了3个月的饮食干预,分别接受LCD和低脂饮食(LFD),其中a-LCD组22人,LFD组23人。在基线和第3个月评估抑郁症指标和生化指标,包括糖化血红蛋白(HbA1c)、肠道微生物群和GLP-1水平,并比较两组之间的差异。

 

结果显示,A-LCD显著改善了抑郁症和HbA1c(P <0.01)。同时,a-LCD显著增加了产短链脂肪酸(SCFAs)的细菌罗氏菌属、瘤胃球菌属和优杆菌属。a-LCD组的GLP-1水平显著高于LFD组(P<0.05)。

综上所述,该研究结果表明,a-LCD有益于T2DM患者的抑郁症和糖代谢。研究人员推测,a-LCD在改善T2DM患者抑郁症方面的作用可能与其刺激SCFAs生产菌的生长,增加SCFAs的产生和GPR43的激活,进一步维持GLP-1的分泌有关。未来研究应进一步考察SCFAs和GPR43的激活情况。

 

原始出处:

 

Mengxiao Ren, et al., An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial. Nutrients. 2020 Oct 3;12(10):3036. doi: 10.3390/nu12103036.

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    2021-04-21 zz70
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  5. 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    2021-04-21 yuanming9
  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1906454, encodeId=ab40190645480, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Thu Aug 26 11:30:31 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345132, encodeId=18731345132f9, content=<a href='/topic/show?id=c2462629612' target=_blank style='color:#2F92EE;'>#低碳水化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26296, encryptionId=c2462629612, topicName=低碳水化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Tue Apr 20 00:22:20 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-20 139a948em49暂无昵称

    加油

    0

  9. 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    2021-04-20 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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    2021-04-20 ZJYYY7

    emmmm

    0

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