JACC:经心外膜左心耳消融术会明显降低房颤患者血压!

2018-09-14 MedSci MedSci原创

经皮左心耳消融术(LAAE)可作为预防房颤患者卒中发生的一种手段,近期研究显示心外膜的LAAE对心律失常负荷和血流动力学有显着影响。本研究目的旨在比较和评估心外膜和心内膜LAAE对房颤伴高血压患者全身血压的影响。本次前瞻性非随机临床试验纳入比较了247名接受心外膜LAAE和124名接受心内膜LAAE的房颤患者,临床指标在术后3个月和术后1年进行测量。主要终点事件是收缩压(SBP)的提高,次要终点事

经皮左心耳消融术(LAAE)可作为预防房颤患者卒中发生的一种手段,近期研究显示心外膜的LAAE对心律失常负荷和血流动力学有显着影响。本研究目的旨在比较和评估心外膜和心内膜LAAE对房颤高血压患者全身血压的影响。

本次前瞻性非随机临床试验纳入比较了247名接受心外膜LAAE和124名接受心内膜LAAE的房颤患者,临床指标在术后3个月和术后1年进行测量。主要终点事件是收缩压(SBP)的提高,次要终点事件是舒张压、血清电解质和肌酐的变化。分析结果显示,基础的SBP在两组患者间无明显差异,与心内膜LAAE组相比,接受心外膜LAAE患者的SBP在术后3个月和术后1年均要明显更低,调整的多元线性混合效应模型显示心外膜LAAE组患者的SBP在术后3个月明显下降7.4mmHg,术后1年明显下降了8.9mmHg(p < 0.0001)。另外,舒张压在心外膜组中也有下降的趋势,血清电解质和肌酐水平无明显差异。

研究结果显示,在房颤伴高血压患者中,与心内膜消融术相比,心外膜左心耳消融术会明显降低患者收缩压水平。

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    2018-12-13 hbwxf
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    2018-09-16 jxrzshh
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    2018-09-14 天地飞扬

    了解一下,谢谢分享!

    0

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