Eur J Heart Fail:围产期心肌病女性高血压疾病情况

2021-09-13 MedSci原创 MedSci原创

根据PPCM女性的高血压状态,她们在表型、心脏功能恢复和新生儿结局方面存在差异。

患有围产期心肌病(PPCM)的女性会发生高血压疾病。合并高血压疾病的频率以及它们对结局的影响程度尚未明确。

近日,血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章,研究人员描述了妊娠期间患有和不患有高血压疾病的PPCM女性在表型和结局方面的差异。

欧洲心脏病学会欧洲观察研究计划PPCM登记处从2012年到2018年招募了患有PPCM的女性。研究人员评估了三组:(i)没有高血压的女性(PPCM-noHTN);(ii)患有高血压但没有先兆子痫的女性(PPCM-HTN);(iii)患有先兆子痫(PPCM-PE)的女性。对孕产妇(6个月)和新生儿结局进行了比较。

在纳入的735名女性中,452名(61.5%)患者为PPCM-noHTN,99名(13.5%)患者为PPCM-HTN,184名(25.0%)患者为PPCM-PE。与PPCM-noHTN的女性相比,PPCM-PE的女性有更严重的症状(纽约心脏协会IV级,分别为44.4% vs. 29.9%,P<0.001)、更频繁的心力衰竭迹象(肺啰音为70.7% vs. 55.4%,P=0.002),更高的基线左心室射血分数(LVEF)(32.7% vs. 30.7%,P=0.005)和更小的左心室舒张末期直径(57.4±6.7mm vs. ±1.8mm)mm,P=0.001)。全因死亡、全因再住院、卒中血栓栓塞事件的发生率没有差异。与PPCM-noHTN女性相比,PPCM-PE女性左心室恢复的可能性更大(LVEF≥50%)(调整比值比为2.08,95%置信区间为1.21-3.57)和不良新生儿结局(终止妊娠、流产、低出生体重或新生儿死亡的复合事件)(调整后的比值比为2.84,95%置信区间为1.66–4.87)。
 
由此可见,根据PPCM女性的高血压状态,她们在表型、心脏功能恢复和新生儿结局方面存在差异。

原始出处:

Alice M. Jackson.et al.Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry.European journal of heart failure.2021.https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2264

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    2021-09-14 zhaojie88
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    2021-09-14 slcumt
  6. [GetPortalCommentsPageByObjectIdResponse(id=1765149, encodeId=1ff91e65149c2, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Jul 18 06:44:41 CST 2022, time=2022-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933284, encodeId=909f193328417, content=<a href='/topic/show?id=a2f04062973' target=_blank style='color:#2F92EE;'>#围产期心肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40629, encryptionId=a2f04062973, topicName=围产期心肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon Jan 31 03:44:41 CST 2022, time=2022-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201364, encodeId=343712013649f, content=<a href='/topic/show?id=c65251303fc' target=_blank style='color:#2F92EE;'>#心肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51303, encryptionId=c65251303fc, topicName=心肌病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Thu Mar 10 14:53:00 CST 2022, time=2022-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357784, encodeId=b07e135e784d4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Sep 14 22:44:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563520, encodeId=ac3e156352056, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Sep 14 22:44:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622499, encodeId=0f611622499b7, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Sep 14 22:44:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1017036, encodeId=74e3101e03658, content=围产期这样的病人越来越多,很奇怪,这是为什么呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon Sep 13 14:58:46 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016991, encodeId=fbed1016991c1, content=这样的患者真的很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210913/fd55587126954e5d83083034d5611991/6fecdb4fbaba4c059fa51a401f2d0e4d.jpg, createdBy=c0c55476772, createdName=孙丽, createdTime=Mon Sep 13 10:51:08 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016928, encodeId=a52010169288c, content=lavish…?…!市立医院, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Sep 13 08:23:12 CST 2021, time=2021-09-13, status=1, ipAttribution=)]
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    2021-09-13 病毒猎手

    围产期这样的病人越来越多,很奇怪,这是为什么呢

    0

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    2021-09-13 孙丽

    这样的患者真的很多

    0

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    2021-09-13 查查佳佳

    lavish…?…!市立医院

    0

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