PLOS ONE:维生素A预防极低出生体重儿的支气管肺发育不良

2018-12-01 海北 MedSci原创

研究人员进行进一步的探究,以阐明VA补充剂对极低出生体重婴儿(ELBWIs)预防BPD的作用。

已有的研究显示,维生素A(VA)补充剂可降低患支气管肺发育不良(BPD)的风险。然而,之前的一项荟萃分析显示,VA在极低出生体重婴儿(VLBWIs)中预防BPD的疗效极差。因此,研究人员进行进一步的探究,以阐明VA补充剂对极低出生体重婴儿(ELBWIs)预防BPD的作用。

该系统评价和荟萃分析遵循系统评价和Meta分析的首选报告项目(PRISMA)指南。研究人员在PROSPERO上注册了该协议,PROSPERO是系统评价的国际预期登记处(注册号:CRD42016050887)。研究人员搜索了以下五个数据库:CINAHL,CENTRAL,EMBASE,MEDLINE和PubMed,筛选了检索文章的参考文献清单,以确定随机对照试验(RCTs);并评估每项研究的Cochrane偏倚风险。此外,研究人员使用建议评估,发展和评估(GRADE)指南评估证据的确定性。

最终,共有四项研究(总数,1,011名婴儿)被包括其中。 VA在3项研究中肌肉内给药,在1项研究中口服给药。 ELBWIs的VA补充剂使幸存者在36周的经后年龄时受益于氧依赖性(合并风险比,0.88;95%置信区间(CI),0.77-0.99; 4项试验,841名婴儿,中等确定性证据),这类似于VLBWI中的荟萃分析。 VA组住院时间缩短(平均差异,-49.9; 95%CI,-88.78至-11.02; 1例试验,20例婴儿,证据确凿度低)。荟萃分析显示新生儿死亡,幸存者28天的氧气使用,机械通气持续时间,脑室内出血,早产儿视网膜病变和坏死性小肠结肠炎的风险没有降低。

因此,用于ELBWI的VA补充剂可有效降低36周的经后年龄的胎儿的氧依赖性。


原始出处:

Araki S et al. Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis. PLOS ONE, 2018; doi: 10.1371/journal.pone.0207730. eCollection 2018.


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createdName=zjubiostat, createdTime=Thu Jul 11 00:29:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790303, encodeId=00661e90303ed, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Mar 18 18:29:00 CST 2019, time=2019-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354374, encodeId=ee2a3543e453, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49ec2274185, 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encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420027, encodeId=6bf2142002e9b, content=<a href='/topic/show?id=ae62e905291' target=_blank style='color:#2F92EE;'>#维生素A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79052, encryptionId=ae62e905291, topicName=维生素A)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c60e3553736, createdName=wwzzly, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440751, encodeId=78221440e51d7, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567976, encodeId=3ff5156e97659, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571481, encodeId=13fa15e148141, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=)]
    2018-12-03 121afdd5m30暂无昵称

    学习啦

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1808720, encodeId=7c241808e20bb, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Tue Feb 05 15:29:00 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892184, encodeId=7dfb18921845a, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, 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createdName=121afdd5m30暂无昵称, createdTime=Mon Dec 03 21:37:13 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347355, encodeId=385f134e35518, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374306, encodeId=e32313e43063d, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420027, encodeId=6bf2142002e9b, content=<a href='/topic/show?id=ae62e905291' target=_blank style='color:#2F92EE;'>#维生素A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79052, encryptionId=ae62e905291, topicName=维生素A)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c60e3553736, createdName=wwzzly, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440751, encodeId=78221440e51d7, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567976, encodeId=3ff5156e97659, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571481, encodeId=13fa15e148141, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=)]
    2018-12-03 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1808720, encodeId=7c241808e20bb, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Tue Feb 05 15:29:00 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892184, encodeId=7dfb18921845a, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, 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encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420027, encodeId=6bf2142002e9b, content=<a href='/topic/show?id=ae62e905291' target=_blank style='color:#2F92EE;'>#维生素A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79052, encryptionId=ae62e905291, topicName=维生素A)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c60e3553736, createdName=wwzzly, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440751, encodeId=78221440e51d7, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, 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  7. 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encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420027, encodeId=6bf2142002e9b, content=<a href='/topic/show?id=ae62e905291' target=_blank style='color:#2F92EE;'>#维生素A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79052, encryptionId=ae62e905291, topicName=维生素A)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c60e3553736, createdName=wwzzly, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440751, encodeId=78221440e51d7, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, 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content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Dec 03 09:29:00 CST 2018, time=2018-12-03, status=1, ipAttribution=)]
    2018-12-03 wwzzly
  8. 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