Medicine:罗哌卡因联合右美托咪定用于骶管麻醉对痔切除术患者的镇痛作用的影响:前瞻性随机对照试验

2019-01-30 anesthGH “ 罂粟花”公众号

右美托咪定作为罗哌卡因的辅助用药,延长了骶管阻滞的持续时间,改善了术后镇痛,且其对接受痔切除术的成年患者没有明显的副作用。

背景与目的

探讨右美托咪定联合罗哌卡因对痔切除术患者感觉阻滞开始时间、阻滞持续时间及麻醉结束后镇痛效果的影响。

方  法

50例成人痔切除术患者分为2组。罗哌卡因组(R组):18 mL 0.3%罗哌卡因+ 2 mL生理盐水进行骶管麻醉。罗哌卡因联合右美托咪定组(RD组):18 mL 0.3% 罗哌卡因+2毫升1μg /kg右美托咪定。观察心率、平均血压、感觉阻滞开始时间、持续时间、镇痛持续时间。

结 果

与R组比较,RD组感觉阻滞的起效时间缩短(9.2±1.3 vs 7.2±1.2),感觉阻滞的持续时间(3.0±0.7 vs 3.8±0.8)和镇痛持续时间(3.9±0.7 vs 5.3±0.8)延长(P <.05)。 除基线外,各组观察时间点RD组心率和平均动脉压均低于R组(P <.05)。试验中无心动过缓或低血压事件发生。

结 论

右美托咪定作为罗哌卡因的辅助用药,延长了骶管阻滞的持续时间,改善了术后镇痛,且其对接受痔切除术的成年患者没有明显的副作用。

原始文献摘要

Deming X, Mingyu X, Xiaobao Z, et al. Effect of dexmedetomidine added to ropivicaine for caudal anesthesia in patients undergoing hemorrhoidectomy. Medicine, 2018, 97(34): e11731.

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    2019-03-20 jeanqiuqiu
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    2019-10-16 amyloid
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    2019-12-18 kalseyzl
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  5. 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    2019-01-31 zhaojie88
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剖宫产后,术后疼痛管理可以促进早期康复,有助于预防产后抑郁症和慢性疼痛。目前的前瞻性、随机对照、双盲研究评估了剖宫产分娩后鞘内镇痛和连续罗哌卡因伤口浸润的持续时间和作用。主要结局是镇痛持续时间,其定义为首次增加使用吗啡的时间。次要结局是术后吗啡的累积用量,不需使用吗啡的患者数量,不良反应的发生率和首次下床活动的时间。

Anesthesiology:胸段硬膜外镇痛对下尿路功能的影响:罗哌卡因与布比卡因的比较

布比卡因胸段硬膜外镇痛可导致临床相关的由于逼尿肌松弛而引起的尿液残留。本研究通过评估尿液残留量和最大流量速率,从而比较使用罗哌卡因与布比卡因对膀胱功能障碍的影响程度。我们的假设为罗哌卡因会导致较低水平的尿液残留,由于已证明罗哌卡因对运动神经阻滞的作用较小。

Brit J Ophthal:上海九院汪朝阳教授发现玻璃体切割术间使用罗哌卡因疼痛和出血风险更低

为了比较1%罗哌卡因(Ropivacaine), 0.75%布比卡因(Bupivacaine), 2%利多卡因以及0.75%丁哌卡因和2%利多卡因(bupi+lido)的混合制剂在玻璃体切除术球周麻醉的术中和术后临床特性。中国上海交通大学附属第九人民医院汪朝阳教授和新华医院的研究人员开展了一项前瞻性随机双盲临床研究。该研究于2月7日在 British Journal of Ophthal