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J Periodontal Res：不同品系小鼠对种植体周围炎的敏感性

2018-04-03 MedSci MedSci原创

种植体周围炎骨吸收
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种植体周围炎（PI）是影响种植体使用的重要因素。虽然PI的发病机制尚未完全明了，但有证据表明，PI是多因素疾病，其中可能包括遗传因素。本研究的目的是调查遗传学在种植体周围炎发展中的作用。

种植体周围炎（PI）是影响种植体使用的重要因素。虽然PI的发病机制尚未完全明了，但有证据表明，PI是多因素疾病，其中可能包括遗传因素。本研究的目的是调查遗传学在种植体周围炎发展中的作用。

将四周龄的C57BL / 6J，C3H / HeJ和A / J雄性小鼠的左侧上颌磨牙拔除，然后将种植体植入拔牙窝中。在骨整合时，将结扎物放置在种植体头周围1或4周以诱导PI。微型计算机断层扫描来测量骨吸收体积，组织学分析评估胶原蛋白组织和中性粒细胞和破骨细胞。

结果：影像学显示，结扎处理的小鼠中，C57BL / 6J显示骨吸收量最大，然后是1周和4周C3H / HeJ和A / J小鼠。组织学显示，1周时，C57BL / 6J小鼠嗜中性粒细胞和破骨细胞数量最多。在第4周时，C57BL / 6J小鼠骨重塑最活跃。

结论：不同小鼠品系之间种植体周围炎的严重程度存在显着差异，表明遗传框架可影响种植体的存活和成功。未来的工作需要分析基因对种植体周围炎发展的贡献。

原始出处：

S. Hiyari， et al. Susceptibility of different mouse strains to peri‐implantitis. Journal of Periodontal Research. 2018 February. doi：10.1111/jre.12493

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    2019-02-04 feather89

    #PE#

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    2019-01-24 huangdf

    #种植#

    0

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    2018-04-05 ms5236388012055669

    #敏感性#

    0

  4. 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    2018-04-05 ms6279672939590805

    #种植体#

    0

  5. 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    2018-04-04 wzb521zf

    一起学习学习

    0

  6. 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    2018-04-04 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Apr 05 14:23:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302623, encodeId=145630262364, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Apr 04 08:20:20 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302592, encodeId=060c30259259, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Apr 04 07:25:20 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302582, encodeId=bb533025821c, content=不停的数中也似有不一样的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:11:16 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302581, encodeId=f19230258126, content=计算假期快来帮忙着, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:57 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302580, encodeId=f4a3302580e0, content=如何排除这些相关映像, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:49 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302579, encodeId=75863025e98c, content=似乎在研究中这些也适应新曲之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:40 CST 2018, time=2018-04-04, status=1, ipAttribution=)]
    2018-04-04 雾夜芭蕾

    不停的数中也似有不一样的结果

    0

  8. 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createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:49 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302579, encodeId=75863025e98c, content=似乎在研究中这些也适应新曲之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:40 CST 2018, time=2018-04-04, status=1, ipAttribution=)]
    2018-04-04 雾夜芭蕾

    计算假期快来帮忙着

    0

  9. 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createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:49 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302579, encodeId=75863025e98c, content=似乎在研究中这些也适应新曲之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Wed Apr 04 07:10:40 CST 2018, time=2018-04-04, status=1, ipAttribution=)]
    2018-04-04 雾夜芭蕾

    如何排除这些相关映像

    0

  10. 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    2018-04-04 雾夜芭蕾

    似乎在研究中这些也适应新曲之一

    0

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