PNAS & Plos One :空气污染会导致认知能力下降,还会威胁肾脏?

2018-08-30 佚名 中国生物技术网

来自北京师范大学、耶鲁大学和北京大学的三位研究人员发现,空气污染与人类认知能力下降之间存在关联。他们的这项研究发表在8月27日的《美国国家科学院院刊》上,三位研究人员分别是Xin Zhang, Xi Chen和Xiaobo Zhang,他们在PNAS上个描述了在研究中取得的发现。

来自北京师范大学、耶鲁大学和北京大学的三位研究人员发现,空气污染与人类认知能力下降之间存在关联。他们的这项研究发表在8月27日的《美国国家科学院院刊》上,三位研究人员分别是Xin Zhang, Xi Chen和Xiaobo Zhang,他们在PNAS上个描述了在研究中取得的发现。

几乎所有人都知道空气污染会导致身体疾病,尤其是与肺相关的疾病,但是新证据表明,它还会对精神造成损伤。研究人员在其他研究的基础上取得了这个发现,即空气污染会造成认知能力下降。

在这项研究中,三位研究人员对生活在中国162个县的25000名受测者进行了数学和语言测试,并将结果与空气污染条件下的结果进行了比较。研究人员指出,这项研究的受测者涵盖从青少年到老年的男性和女性。

研究人员发现,空气污染越严重,年龄越大的人测试得分越低。他们指出,影响最大的是男性,尤其是那些受教育程度较低的男性。研究人员认为,这可能是因为在中国教育程度低的男性更多地在室外工作,因此更容易暴露于空气污染中。他们还指出,认知能力衰退是随着时间推移而渐进发生的,这一事实表明空气污染就是造成认知能力衰退的重要指标,而非其他因素。他们认为,这些发现进一步证明长期暴露于空气污染中会引起认知能力衰退。此外,他们还发现了一些神经退行性疾病发病率增加的证据。

研究人员们承认,他们的确不知道空气污染是如何导致认知衰退的,但是他们认为可能是大脑中的白质受到了影响,因为大脑白质负责协调不同大脑区域之间的通信。此外,尚不清楚空气污染成分是否有影响。在他们的研究中,研究人员只测试了氮氧化物、二氧化硫以及直径小于10微米的颗粒(PM10),而没有考虑到一氧化碳、臭氧和更大颗粒物质所造成的影响。

目前,已有充分的证据表明,受空气污染会增加哮喘等呼吸系统疾病的风险,还会增加器官炎症、糖尿病恶化,甚至导致其他威胁生命的疾病。但是,最近一项研究表明,空气污染的害处不仅于此,它还会导致慢性肾病(CKD),CKD指的是患者的肾脏受损或无法正常过滤血液。美国密歇根大学在《PLOS ONE》上发表的这项新研究强调了这种不为人知的关联。

研究第一作者,密歇根大学的流行病学专家Jennifer Bragg-Gresham博士说:“与吸烟相似,被污染的空气中也含有有害毒素,会直接影响肾脏。大量的血液会流经肾脏,如果循环系统遭到破坏,肾脏会是第一个感知到这些影响的。”

糖尿病、肥胖症、高血压以及心脏病患者患CKD的风险更高。所以,这就是为什么生活在人口稠密或污染严重地区的高危患者应该认识到危险并采取预防措施的原因。

为什么空气污染很危险

被污染的空气中含有微小颗粒物质,或者叫做PM2.5,它是各种微粒的混合物。

因为这些微粒重力极其微小,所以它们会在空气中长时间停留,导致人们在不知情的情况下不可避免地吸入它们。如果经常吸入PM2.5,就会导致严重的健康问题。

通过回顾美国医疗保险索赔数据以及美国疾病控制与预防中心的空气质量数据,研究人员们发现,CKD发病率与PM2.5浓度之间存在正相关关系。

密歇根大学的肾病学家Rajiv Saran同时也是美国肾脏数据系统协调中心的负责人,他说:“空气污染严重的地区比空气状况良好地区的慢性肾病发病率更高。”

根据这项新研究引用的数据,美国大约有2700万慢性肾病患者,而患有CKD的人患血管疾病的风险增加了八倍。

但不幸的是,PM2.5几乎无法避免。

我们的日常生活中充满了空气污染,比如做饭和开车。其他的因素还包括吸烟、燃烧木材、包装喷雾产品、家用电器,以及最明显的工业污染和汽车排放。

被污染的空气中还含有重金属,比如铅、汞和镉,所有这些重金属元素对肾脏都有负面作用。

问题及预防措施

密歇根大学的研究人员回顾了过去的一些相关研究,包括一项在阿帕拉契亚(美国东部一个地区)煤矿地区进行的研究。该研究发现,相比于生活在非煤矿地区的人,这里的男性和女性患CKD的风险分别高出19%和13%。

密歇根大学的助理研究员Bragg-Gresham说:“对于高PM2.5的国家来说,这也意味着CKD发病率更高。我们的研究只关注了美国,而美国的PM2.5波动范围很小,但是尽管如此我们还是发现二者之间存在明显关联。”

然而,在面临空气污染时,采取防护措施还是非常重要的,尤其是对于有呼吸问题的人以及生活在严重污染地区的人。

Saran说:“在污染严重的地区,及时戴上口罩来遮住口鼻,减少户外活动时间,并减少在交通繁忙时段的通勤时间,我们一定要严肃对待这一风险。很多人没有意识到空气污染的严重性,因为空气污染并不总是可见的,但是这并不意味着空气污染对身体没有影响。”

原始出处:
1. Xin Zhang, Xi Chen, and Xiaobo Zhang, et al. The impact of exposure to air pollution on cognitive performance. PNAS,  August 27, 2018.

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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun Sep 30 07:30:04 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342304, encodeId=3d8d34230450, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Sep 02 19:38:12 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401272, encodeId=237e14012e20a, content=<a href='/topic/show?id=011f912607c' target=_blank 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createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-10-12 心航

    学习了

    0

  4. 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createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-09-30 Jackie Li

    学习

    0

  5. 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createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-09-02 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  6. 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  7. 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  8. 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createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-08-31 王秀

    学习了,涨知识了!

    0

  9. 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createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-08-31 Jackie Li

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1856208, encodeId=17ff1856208e4, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri May 03 19:22:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790256, encodeId=d62a1e9025632, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Jun 22 00:22:00 CST 2019, time=2019-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349037, encodeId=087934903e34, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/10/12/ef4a9798cd817ef1f4d4bc7fa48c27c8.jpg, createdBy=eb621931675, createdName=心航, createdTime=Fri Oct 12 14:42:25 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347322, encodeId=b56934e32256, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun Sep 30 07:30:04 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342304, encodeId=3d8d34230450, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Sep 02 19:38:12 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401272, encodeId=237e14012e20a, content=<a href='/topic/show?id=011f912607c' target=_blank style='color:#2F92EE;'>#认知能力下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91260, encryptionId=011f912607c, topicName=认知能力下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e642309178, createdName=hukaixun, createdTime=Sat Sep 01 13:22:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472612, encodeId=bdaa14e261266, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat Sep 01 13:22:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342006, encodeId=2976342006bf, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Fri Aug 31 22:37:02 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341924, encodeId=3628341924f1, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Fri Aug 31 08:06:01 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341896, encodeId=5d143418969c, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Aug 31 06:57:15 CST 2018, time=2018-08-31, status=1, ipAttribution=)]
    2018-08-31 liumin1987

    谢谢分享,学习了。

    0

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