Heart:妊娠高血压疾病后孕产妇的心血管风险

2020-05-21 MedSci原创 MedSci原创

在这个全国代表性的澳大利亚队列中,HDP,尤其是发病较早的HDP女性CVD风险明显增加,并通过吸烟而放大。在妊娠期间和之后进行有针对性的预防性保健,可以预防育龄妇女的CVD负担。

妊娠高血压疾病(HDP)影响5%至10%的妊娠,并与过多的母体心血管疾病(CVD)风险相关。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这项研究的主要目的是估计HDP后CVD的绝对和相对风险。

研究人员回顾性地分析2002年至2016年期间在澳大利亚新南威尔士州的单胎妊娠妇女,并使用相关的人口健康管理数据库进行确定。该研究的主要暴露因素为新发HDP(先兆子痫/子痫和妊娠高血压),该研究的终点是因缺血性或高血压性心脏病或卒中而住院或死亡。Kaplan-Meier分析估计了母亲的风险,多变量时间相关的Cox回归估计了HDP与CVD之间的关联。

在528106名妇女中,有10.3%的妇女在第一次怀孕时经历了HDP。如果没有HDP,则10年的CVD风险估计为每1000人中有2.1人,发生HDP则每1000人中有5.5人。调整人口统计学特征、妊娠糖尿病、小于胎龄儿和早产,研究人员发现吸烟与HDP之间存在交互作用,与晚期HDP相比,早期HDP(<34周)的影响更大。与没有HDP的女性相比,不吸烟的早发HDP女性HR为4.90(95%CI为3.00至7.80),吸烟的女性HR为23.5(95%CI为13.5至40.5),相比于不抽烟的无HDP女性。

由此可见,在这个全国代表性的澳大利亚队列中,HDP,尤其是发病较早的HDP女性CVD风险明显增加,并通过吸烟而放大。在妊娠期间和之后进行有针对性的预防性保健,可以预防育龄妇女的CVD负担。

原始出处:

Clare Arnott.et al.Maternal cardiovascular risk after hypertensive disorder of pregnancy.heart.2020.https://heart.bmj.com/content/early/2020/05/13/heartjnl-2020-316541

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    2020-05-23 zhaojie88
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    2020-05-23 slcumt
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    2020-05-22 IVF密密

    妊娠高血压这一类妊娠疾病,需要加强关注,甚至包括妊娠心肌病

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