以四肢皮损为主要表现的蕈样肉芽肿 1 例

2017-12-30 佚名 临床皮肤科杂志

患者男,75岁。

【一般资料】

患者男,75岁。

【主诉】

四肢红斑及结节反复发作6年,于2013年6月来天津市南开医院皮肤科就诊。

【现病史】

6年前患者双侧上肢无明显诱因出现数个近环形红色斑片,轻度瘙痒,外院诊为“环形红斑”,予口服抗生素、外用糖皮质激素治疗(具体不详),效果不明显。此后,一直外用糖皮质激素治疗,无明显好转。近两年皮损渐加重、增多,四肢出现结节、红斑、鳞屑及坏死,愈后色素沉着,部分皮损自行破溃,愈合缓慢,偶有轻度瘙痒。

【既往史】

20年前因“脑瘤”行手术切除。家族史:家族中无类似疾病患者。

【体格检查】

体形消瘦,全身浅表淋巴结未触及增大,系统检查无异常。皮肤科检查:全身皮肤稍干燥,四肢散在暗红色圆形、环形斑片及斑块;部分圆形斑块中心有浸润性结节,部分结节表面破溃,上覆坏死的皮肤及血痂,双侧膝关节处红斑融合成片(图1A),手部皮损上覆粘着性鳞屑(图1B),不易刮除,Auspitz征阴性,右膝关节伸侧红斑基础上可见结节(1C),其余四肢皮疹无明显鳞屑,似有薄膜现象。消退期皮损自中央消退,形成环形色素沉着(图1D、E)。治疗过程中右腿外侧即将脱落的叠瓦状鳞屑(图1F)及左手背出现紫癜样皮损(图1G)。



【辅助检查】

右上臂红斑丘疹组织病理检查:基底细胞液化变性,明显的单一核细胞的亲表皮现象,真皮浅中层淋巴细胞灶状浸润(图2A);表皮内Pautrier微脓肿,可见核分裂象(图2B)。



【治疗】

卤米松乳膏外用,早晚各1次,窄谱中波紫外线(UVB)照射,0.8J/cm2,每周2次。清热凉血活血中药。照射4周后结节消失,双侧上肢皮损基本消失,双侧膝盖斑块消失,仅留色素沉着,仍在治疗随访中。

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    2018-01-02 三生有幸9135

    学习一下谢谢分享

    0

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  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-31 yfjms

    学习

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-31 swfzhanggui

    如果有图片.这个病例就更完美了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-31 swfzhanggui

    非常好的病例.谢谢专家分享

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 changjiu

    学习一下谢谢

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 xiaotao112411

    学习学习学习

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Dec 30 22:57:00 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 xiaotao112411

    学习学习学习

    0

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