Ann Intern Med:非心脏手术后房颤与卒中、心律失常和死亡的关系

2022-08-05 MedSci原创 MedSci原创

与非手术房颤相比,非心脏手术后房颤与血栓栓塞的风险相似。该研究的结果对术后房颤的早期和后续治具有重要的意义。

非心脏手术后发生的房颤会增加缺血性卒中和短暂性脑缺血发作的风险。非心脏手术后房颤与非手术环境下发生的房颤结局有何异同尚不清楚。

近日,内科学权威杂志Annals of Internal Medicine上发表了一篇研究文章,该研究旨在比较术后房颤患者与手术无关的房颤患者发生缺血性卒中或短暂性脑缺血发作的风险和其他结局。

该研究是在美国明尼苏达州奥姆斯特德县完成的队列研究。参与者为2000年至2013年期间发生房颤的患者。患者被分为在非心脏手术后30天内发生的房颤(术后房颤)和与手术无关的房颤(非手术房颤)。

在4231例偶发房颤患者中,550例(13%)例患者为术后房颤。在6.3年的平均随访中,486例患者发生缺血性卒中或短暂性脑缺血发作,2462例患者随后发生房颤,共有2565人死亡。术后房颤和非手术房颤发生卒中或短暂性脑缺血发作的风险相似(5年的绝对风险差为0.1%[95%可信区间为-2.9%至3.1%];风险比为1.01[95%可信区间为0.77-1.32])。术后发生房颤的患者继发房颤的风险较低(5年绝对风险差为-13.4%[95%可信区间为-17.8%至-9.0%];风险比为0.68[95%可信区间为0.60-0.77])。最后,术后房颤患者与非手术房颤患者在心血管死亡或全因死亡方面无差异。

由此可见,与非手术房颤相比,非心脏手术后房颤与血栓栓塞的风险相似。该研究的结果对术后房颤的早期和后续治具有重要的意义。

原始出处:

Konstantinos C. Siontis,et al. Associations of Atrial Fibrillation After Noncardiac Surgery With Stroke, Subsequent Arrhythmia, and Death
A Cohort Study.Ann Intern Med 2022.https://www.acpjournals.org/doi/full/10.7326/M22-0434

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