Stroke:全身恶性肿瘤患者缺血性卒中的短期预后

2019-01-11 xing.T MedSci原创

由此可见,在患有活动性癌症的卒中患者中,癌症转移和癌症类型是与6个月死亡率相关的关键因素。

最近的指南提出静脉溶栓治疗对预期寿命超过6个月且患者全身性恶性肿瘤的卒中患者具有潜在的益处。然而,很难确定哪些癌症患者的预期寿命超过6个月。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确与急性缺血性卒中和全身恶性肿瘤患者6个月死亡相关的因素。

研究人员回顾性地分析了患有全身性恶性肿瘤的连续就诊的卒中患者,并将患者分为3组:非活动性癌症组、活动性非转移性癌症组和转移性癌症组。研究人员比较了基线特征和6个月的存活率。

在8年随访期间468名患有全身性恶性肿瘤的缺血性卒中患者中,223名患者患有非活动性癌症,105名患者具有活跃的非转移性癌症,140名患者具有转移性癌症。在6个月的随访期间,122名患者(26.1%)死亡(非活动性癌症组[7.2%,16/223],活动性非转移性癌症组[11.4%,12/105]和转移性癌症组[67.1%,94/140])。多变量Cox回归分析显示转移(风险比为4.527; 95%CI为2.175-9.422)与6个月的死亡率独立相关。然而,活跃的非转移性癌症组显示出与非活动性癌症组相似的6个月死亡率(风险比为0.711; 95%CI为0.282-1.795)。/食道癌和胰腺癌也与6个月的死亡率独立相关(风险比分别为2.068和2.389)。

由此可见,在患有活动性癌症的卒中患者中,癌症转移和癌症类型是与6个月死亡率相关的关键因素。

原始出处:

Joonsang Yoo.et al.Short-Term Outcome of Ischemic Stroke Patients With Systemic Malignancy.Stroke.2018.https://doi.org/10.1161/STROKEAHA.118.023044

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    2019-01-19 phoebeyan520

    学习了

    0

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    2019-01-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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