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Gastroenterology：遗传性弥漫性胃癌患者内镜特征研究

2019-04-09 MedSci MedSci原创

遗传性弥漫性胃癌内镜CDH1基因
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研究认为，有半数以上的CDH 1种系变异个体在内镜和/或胃切除术中有DGC的组织病理学证据，但DGC家族史和内镜检查结果不能作为遗传易感性DGC个体SRCC风险的决定因素。

CDH 1基因与弥漫性胃癌(DGC)和小叶性乳腺癌风险增加相关。目前由于内镜检测灵敏度有限，因此建议对病源性或可能致病性(PLP)的CDH1携带者进行预防性胃切除术。近日研究人员考察了DGC家族史与CDH 1中 PLP携带者内镜结果的相关性。

1998-2018年间，研究人员对 13个有CDH1种系PLP变体的家庭进行了评估。对有无DGC家族史的个体进行食管、胃、十二指肠镜检查、组织病理学分析和手术结果进行比较。

研究共考察了20例生殖细胞CDH 1型PLP变异携带者，患者接受了内镜检查和/或胃切除术，所有患者内镜检查均无异常。20人中有12人检测到印戒细胞癌(SRCC)。除了一种以外，所有的癌病变均是微小的，且仅限于固有层薄层，1种癌病变为透壁病变。在12名SRCC患者中，有7名的一级亲属未诊断出DGC。

研究认为，有半数以上的CDH 1种系变异个体在内镜和/或胃切除术中有DGC的组织病理学证据，但DGC家族史和内镜检查结果不能作为遗传易感性DGC个体SRCC风险的决定因素。

原始出处：


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    2019-10-12 许安

    #GAS#

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    2019-10-27 huhuaidong400

    #胃癌患者#

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    2020-01-16 ms24272190615788285182

    #AST#

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topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-07-10 sunmin0219

    #遗传性弥漫性胃癌#

    0

  5. 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    2019-09-14 般若傻瓜

    #遗传性#

    0

  6. 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topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-05-01 jktdtl

    #Gastroenterol#

    0

  7. 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topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-04-11 jiafufeng@yaho

    #内镜#

    0

  8. 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encodeId=984d1438606e8, content=<a href='/topic/show?id=9851500416c' target=_blank style='color:#2F92EE;'>#弥漫性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50041, encryptionId=9851500416c, topicName=弥漫性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504651, encodeId=4d94150465136, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-04-11 zhouqu_8

    #弥漫性#

    0

  9. 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encodeId=984d1438606e8, content=<a href='/topic/show?id=9851500416c' target=_blank style='color:#2F92EE;'>#弥漫性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50041, encryptionId=9851500416c, topicName=弥漫性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504651, encodeId=4d94150465136, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-04-11 chaojitidian

    #Gastroenterology#

    0

  10. 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topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 11 11:09:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364422, encodeId=c7c336442218, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Apr 10 13:30:42 CST 2019, time=2019-04-10, status=1, ipAttribution=)]
    2019-04-10 王秀

    学习了，涨知识了！

    0

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