Am J Transl Res:丙泊酚联合艾司胺酮麻醉诱导对老年患者围术期应激和炎症反应及术后认知的影响

2021-05-31 “罂粟花”公众号 “罂粟花”公众号

分析丙泊酚联合艾司氯胺酮麻醉诱导对老年患者围手术期应激、炎症反应及术后认知的影响。

目的

分析丙泊酚联合艾司氯胺酮麻醉诱导对老年患者围手术期应激、炎症反应及术后认知的影响。

方法

将80例老年外科手术患者随机分为对照组(n=40)和实验组(n=40),对照组给予丙泊酚联合舒芬太尼诱导,实验组使用丙泊酚联合艾司氯胺酮麻醉诱导;比较两组患者的血流动力学、应激和炎症反应、认知功能变化、围术期相关指标及不良反应情况。

结果

两组患者T1时的肾上腺素、去甲肾上腺素、内皮素、C反应蛋白、白细胞、降钙素原水平与T0时相比无明显变化,T2、T3时的各指标水平均较T1时升高,而T4的各项指标水平与T0接近,且实验组高于对照组,上述指标在组间、时间点上、组与时间点之间交互水平比较,差异均具有统计学意义(P<0.05)。术后24h,两组患者蒙特利尔认知评估量表(MoCA)评分均下降,且实验组MoCA评分高于对照组(P<0.05);实验组麻醉时间及意识恢复时间均短于对照组(P<0.05)。

注:(麻醉前(T0)、麻醉开始时(T1)、麻醉后30 min (T2)、手术结束时(T3)、术后12 h (T4))

结论

丙泊酚联合艾司氯胺酮麻醉诱导,具有良好的安全性和可靠性,可改善血流动力学及手术应激及炎症反应,缩短麻醉时间,促进术后认知功能恢复,不良反应相对较轻。

原始出处:

Tu W , Yuan H , Zhang S , et al.  Influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition of elderly surgical patients[J]. American Journal of Translational Research, 2021, 13(3):1701-1709.

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