Lancet:乙脑疫苗或能对抗超级淋病

2017-07-12 宗华 科学网

一种针对乙型脑膜炎的疫苗或能阻止耐抗生素的超级淋病的扩散。

一种针对乙型脑膜炎的疫苗或能阻止耐抗生素的超级淋病的扩散。

人类急需针对这种性传播感染的疫苗。近日,世界卫生组织(WHO)报告称,在77个寻找耐抗生素的淋病的国家中,有81%发现了对azithromycin具有抵抗力的菌株。Azithromycin是用于对抗淋病的主要抗生素。

WHO表示,目前仅有3种对抗淋病的新药正在人群中接受测试。即便这些药物发挥了作用,细菌也会不断进化,从而避开它们。WHO警告称,疫苗“将最终成为控制淋病的唯一的可持续方式”。不过,迄今为止,实验室性疫苗均以失败告终。或许,一种获批的现存疫苗能实现这一目的。

淋病由同脑膜炎双球菌(引发乙型脑膜炎)存在密切关联的淋球菌引起。由于引发乙型脑膜炎和淋病的细菌蛋白序列存在80%~90%的相似性,因此对一种疾病的免疫反应可能影响另一种。

人们不知道原因何在,但乙型脑膜炎的爆发有时会持续十年或20年。上世纪80年代的古巴和挪威以及90年代的新西兰都曾发生过乙型脑膜炎疫情。每次疫情都伴随着特制疫苗的出现。在新西兰,对超过80%的20岁以下人群进行的大规模疫苗接种大大缩短了疫情。

来自美国俄亥俄州辛辛那提儿童医院的Steve Black和同事在分析了临床记录后发现,接受乙型脑膜炎疫苗注射的人群随后感染淋病的可能性比未接种者低31%。与此同时,患有淋病的接种者后期恶化的可能性比未接种者低40%。相关成果日前发表于《柳叶刀》杂志。
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  1. [GetPortalCommentsPageByObjectIdResponse(id=1829078, encodeId=bb7218290e87f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 10 20:26:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221936, encodeId=e8e922193635, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Jul 13 19:00:41 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221453, encodeId=93fb221453e0, content=脑膜炎奈瑟菌引起的是流行性脑脊髓膜炎吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08a2089443, createdName=1551f3efb1m, createdTime=Wed Jul 12 16:06:50 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221437, encodeId=823422143e35, content=使用于临床了吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jul 12 15:12:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2018-06-10 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1829078, encodeId=bb7218290e87f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 10 20:26:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221936, encodeId=e8e922193635, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Jul 13 19:00:41 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221453, encodeId=93fb221453e0, content=脑膜炎奈瑟菌引起的是流行性脑脊髓膜炎吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08a2089443, createdName=1551f3efb1m, createdTime=Wed Jul 12 16:06:50 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221437, encodeId=823422143e35, content=使用于临床了吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jul 12 15:12:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 1dd8c52fm63(暂无匿称)

    了解了解

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1829078, encodeId=bb7218290e87f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 10 20:26:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221936, encodeId=e8e922193635, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Jul 13 19:00:41 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221453, encodeId=93fb221453e0, content=脑膜炎奈瑟菌引起的是流行性脑脊髓膜炎吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08a2089443, createdName=1551f3efb1m, createdTime=Wed Jul 12 16:06:50 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221437, encodeId=823422143e35, content=使用于临床了吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jul 12 15:12:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 1551f3efb1m

    脑膜炎奈瑟菌引起的是流行性脑脊髓膜炎吧

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1829078, encodeId=bb7218290e87f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 10 20:26:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221936, encodeId=e8e922193635, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Jul 13 19:00:41 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221453, encodeId=93fb221453e0, content=脑膜炎奈瑟菌引起的是流行性脑脊髓膜炎吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08a2089443, createdName=1551f3efb1m, createdTime=Wed Jul 12 16:06:50 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221437, encodeId=823422143e35, content=使用于临床了吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jul 12 15:12:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 楠博One

    使用于临床了吗

    0